日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel tricycle expanded purine nucleosides with pan-viral activity

具有泛病毒活性的新型三环扩展嘌呤核苷

Martin-Ghoteimi, Céline; Davis, Kyle A; Ghoteimi, Rayane; Amare, Meareg; Diefenbacher, Meghan V; Kutz, Christianna; Smith, Jessica L; Stevens, Laura J; Tchesnokov, Egor; Walker, Simon M; Denison, Mark; Götte, Matthias; Halfmann, Peter; Hirsch, Alec J; Sheahan, Timothy P; Seley-Radtke, Katherine L

Mechanism and spectrum of inhibition of viral polymerases by 2'-deoxy-2'-β-fluoro-4'-azidocytidine or azvudine.

2'-脱氧-2'-β-氟-4'-叠氮胞苷或阿兹夫定抑制病毒聚合酶的机制和范围

Lee Hery W, Tchesnokov Egor P, Stevens Laura J, Hughes Tia M, Diefenbacher Meghan V, Woolner Emma, Kocincova Dana, Schultz David C, Cherry Sara, Sheahan Timothy P, Denison Mark R, Götte Matthias

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo.

SARS-CoV-2 Mpro 的口服非共价非肽抑制剂可改善体内病毒复制和致病性

Zhou Nian E, Tang Su, Bian Xuelin, Parai Maloy K, Krieger Inna V, Flores Armando, Jaiswal Pradeep K, Bam Radha, Wood Jeremy L, Shi Zhe, Stevens Laura J, Scobey Trevor, Diefenbacher Meghan V, Moreira Fernando R, Baric Thomas J, Acharya Arjun, Shin Joonyoung, Rathi Manish M, Wolff Karen C, Riva Laura, Bakowski Malina A, McNamara Case W, Catanzaro Nicholas J, Graham Rachel L, Schultz David C, Cherry Sara, Kawaoka Yoshihiro, Halfmann Peter J, Baric Ralph S, Denison Mark R, Sheahan Timothy P, Sacchettini James C

Evaluation of in vitro antiviral activity of SARS-CoV-2 M(pro) inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions

SARS-CoV-2 M(pro)抑制剂pomotrelvir体外抗病毒活性评价及其与nirmatrelvir耐药性突变的交叉耐药性

Tong, Xiao; Keung, Walter; Arnold, Lee D; Stevens, Laura J; Pruijssers, Andrea J; Kook, Seunghyi; Lopatin, Uri; Denison, Mark; Kwong, Ann D

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

SARS-CoV-2 RNA依赖性RNA聚合酶的突变通过不同的机制赋予病毒对瑞德西韦的耐药性。

Stevens, Laura J; Pruijssers, Andrea J; Lee, Hery W; Gordon, Calvin J; Tchesnokov, Egor P; Gribble, Jennifer; George, Amelia S; Hughes, Tia M; Lu, Xiaotao; Li, Jiani; Perry, Jason K; Porter, Danielle P; Cihlar, Tomas; Sheahan, Timothy P; Baric, Ralph S; Götte, Matthias; Denison, Mark R

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

SARS-CoV-2 mRNA-1273疫苗接种后反应的持久性

Widge, Alicia T; Rouphael, Nadine G; Jackson, Lisa A; Anderson, Evan J; Roberts, Paul C; Makhene, Mamodikoe; Chappell, James D; Denison, Mark R; Stevens, Laura J; Pruijssers, Andrea J; McDermott, Adrian B; Flach, Britta; Lin, Bob C; Doria-Rose, Nicole A; O'Dell, Sijy; Schmidt, Stephen D; Neuzil, Kathleen M; Bennett, Hamilton; Leav, Brett; Makowski, Mat; Albert, Jim; Cross, Kaitlyn; Edara, Venkata-Viswanadh; Floyd, Katharine; Suthar, Mehul S; Buchanan, Wendy; Luke, Catherine J; Ledgerwood, Julie E; Mascola, John R; Graham, Barney S; Beigel, John H

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

冠状病毒校对外切核糖核酸酶介导广泛的病毒重组

Gribble, Jennifer; Stevens, Laura J; Agostini, Maria L; Anderson-Daniels, Jordan; Chappell, James D; Lu, Xiaotao; Pruijssers, Andrea J; Routh, Andrew L; Denison, Mark R

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

原型病原体防范促进了SARS-CoV-2 mRNA疫苗的研发

Corbett, Kizzmekia S; Edwards, Darin; Leist, Sarah R; Abiona, Olubukola M; Boyoglu-Barnum, Seyhan; Gillespie, Rebecca A; Himansu, Sunny; Schäfer, Alexandra; Ziwawo, Cynthia T; DiPiazza, Anthony T; Dinnon, Kenneth H; Elbashir, Sayda M; Shaw, Christine A; Woods, Angela; Fritch, Ethan J; Martinez, David R; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Hutchinson, Geoffrey B; Bahl, Kapil; Garcia-Dominguez, Dario; Ma, LingZhi; Renzi, Isabella; Kong, Wing-Pui; Schmidt, Stephen D; Wang, Lingshu; Zhang, Yi; Stevens, Laura J; Phung, Emily; Chang, Lauren A; Loomis, Rebecca J; Altaras, Nedim Emil; Narayanan, Elisabeth; Metkar, Mihir; Presnyak, Vlad; Liu, Catherine; Louder, Mark K; Shi, Wei; Leung, Kwanyee; Yang, Eun Sung; West, Ande; Gully, Kendra L; Wang, Nianshuang; Wrapp, Daniel; Doria-Rose, Nicole A; Stewart-Jones, Guillaume; Bennett, Hamilton; Nason, Martha C; Ruckwardt, Tracy J; McLellan, Jason S; Denison, Mark R; Chappell, James D; Moore, Ian N; Morabito, Kaitlyn M; Mascola, John R; Baric, Ralph S; Carfi, Andrea; Graham, Barney S

Self-neutralizing oligonucleotides with enhanced cellular uptake

具有增强细胞摄取能力的自中和寡核苷酸

Yanachkov, Ivan; Zavizion, Boris; Metelev, Valeri; Stevens, Laura J; Tabatadze, Yekaterina; Yanachkova, Milka; Wright, George; Krichevsky, Anna M; Tabatadze, David R

Detection of the virulent form of AVR3a from Phytophthora infestans following artificial evolution of potato resistance gene R3a

通过对马铃薯抗性基因 R3a 进行人工进化,从致病疫霉中检测到毒性形式 AVR3a

Chapman, Sean; Stevens, Laura J; Boevink, Petra C; Engelhardt, Stefan; Alexander, Colin J; Harrower, Brian; Champouret, Nicolas; McGeachy, Kara; Van Weymers, Pauline S M; Chen, Xinwei; Birch, Paul R J; Hein, Ingo