日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Discovery of a Tunable Heterocyclic Electrophile 4-Chloro-pyrazolopyridine That Defines a Unique Subset of Ligandable Cysteines

发现一种可调控的杂环亲电试剂 4-氯吡唑并吡啶，它定义了可配位半胱氨酸的一个独特子集

期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/acschembio.4c00025
Kim, Hong-Rae; Byun, David P; Thakur, Kalyani; Ritchie, Jennifer; Xie, Yixin; Holewinski, Ronald; Suazo, Kiall F; Stevens, Mckayla; Liechty, Hope; Tagirasa, Ravichandra; Jing, Yihang; Andresson, Thorkell; Johnson, Steven M; Yoo, Euna
信号转导
发表日期：2024
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Allosteric differences dictate GroEL complementation of E. coli

变构差异决定了 GroEL 对大肠杆菌的互补作用

期刊:FASEB Journal
影响因子:4.2
doi:10.1096/fj.202101708RR
Sivinski, Jared; Ngo, Duc; Zerio, Christopher J; Ambrose, Andrew J; Watson, Edmond R; Kaneko, Lynn K; Kostelic, Marius M; Stevens, Mckayla; Ray, Anne-Marie; Park, Yangshin; Wu, Chunxiang; Marty, Michael T; Hoang, Quyen Q; Zhang, Donna D; Lander, Gabriel C; Johnson, Steven M; Chapman, Eli
发表日期：2022
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Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol.

双芳基-α,β-不饱和酮 (ABK) 分子伴侣抑制剂对结直肠癌细胞表现出选择性细胞毒性，这与胞质溶胶中异常 HSP60 的水平相关

期刊:Bioorganic & Medicinal Chemistry
影响因子:3
doi:10.1016/j.bmc.2022.117072
Chitre Siddhi, Ray Anne-Marie, Stevens Mckayla, Doud Emma H, Liechty Hope, Washburn Alex, Tepper Katelyn, Sivinski Jared, O'Hagan Heather M, Georgiadis Millie M, Chapman Eli, Johnson Steven M
细胞生物学
肠癌
发表日期：2022
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Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.

硝基呋喃类抗生素的类似物是强效的 GroEL/ES 抑制剂前药

期刊:Bioorganic & Medicinal Chemistry
影响因子:3
doi:10.1016/j.bmc.2020.115710
Stevens Mckayla, Howe Chris, Ray Anne-Marie, Washburn Alex, Chitre Siddhi, Sivinski Jared, Park Yangshin, Hoang Quyen Q, Chapman Eli, Johnson Steven M
信号转导
发表日期：2020
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HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules

多种已批准的药物、天然产物和已知的生物活性分子均可抑制HSP60/10分子伴侣系统。

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2019.02.028
Stevens, Mckayla; Abdeen, Sanofar; Salim, Nilshad; Ray, Anne-Marie; Washburn, Alex; Chitre, Siddhi; Sivinski, Jared; Park, Yangshin; Hoang, Quyen Q; Chapman, Eli; Johnson, Steven M
HSP60
发表日期：2019
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Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections

双靶向GroEL/ES分子伴侣和蛋白酪氨酸磷酸酶B (PtpB) 抑制剂：治疗结核分枝杆菌感染的多药理学策略

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2019.04.034
Washburn, Alex; Abdeen, Sanofar; Ovechkina, Yulia; Ray, Anne-Marie; Stevens, Mckayla; Chitre, Siddhi; Sivinski, Jared; Park, Yangshin; Johnson, James; Hoang, Quyen Q; Chapman, Eli; Parish, Tanya; Johnson, Steven M
炎症/感染
发表日期：2019
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