日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PGM1 deficiency is linked to sarcomeric and mitochondrial dysfunction in patient-derived iPSC-cardiomyocytes

PGM1 缺乏与患者来源的 iPSC 心肌细胞的肌节和线粒体功能障碍有关

Radenkovic, Silvia; Preston, Graeme; Budhraja, Rohit; Muffels, Irena; Ligezka, Anna; Staff, Nathan P; Hrstka, Ron; Balakrishnan, Bijina; Shah, Rameen; Verberkmoes, Sanne; Shammas, Ibrahim; Bosnyak, Inez; Stiers, Kyle M; Lai, Kent; Beamer, Lesa J; Pandey, Akhilesh; Morava, Eva; Kozicz, Tamas

PGM1 deficiency disrupts sarcomere and mitochondrial function in a stem-cell cardiomyocyte model

PGM1 缺乏会破坏干细胞心肌细胞模型中的肌节和线粒体功能

Radenkovic, Silvia; Preston, Graeme; Budhraja, Rohit; Muffels, Irena; Ligezka, Anna; Staff, Nathan P; Hrstka, Ron; Balakrishnan, Biijina; Shah, Rameen; Verberkmoes, Sanne; Shammas, Ibrahim; Bosnyak, Inez; Stiers, Kyle M; Lai, Kent; Beamer, Lesa J; Pandey, Akhilesh; Morava, Eva; Kozicz, Tamas

Effects of the T337M and G391V disease-related variants on human phosphoglucomutase 1: structural disruptions large and small

T337M 和 G391V 致病变异对人磷酸葡萄糖变位酶 1 的影响:结构破坏的大小差异

Stiers, Kyle M; Owuocha, Luckio F; Beamer, Lesa J

Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans-4-hydroxy-L-proline.

反式-4-羟基-L-脯氨酸对双脯氨酸/羟脯氨酸分解代谢酶ALDH4A1立体选择性抑制的结构基础

Bogner Alexandra N, Stiers Kyle M, McKay Cole M, Becker Donald F, Tanner John J

Kinetics of human pyrroline-5-carboxylate reductase in L-thioproline metabolism

人吡咯啉-5-羧酸还原酶在L-硫代脯氨酸代谢中的动力学

Patel, Sagar M; Seravalli, Javier; Stiers, Kyle M; Tanner, John J; Becker, Donald F

Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target

脯氨酸生物合成酶吡咯啉-5-羧酸还原酶 (PYCR) 的结构、生物化学和基因表达模式,一种新兴的癌症治疗靶点

Bogner, Alexandra N; Stiers, Kyle M; Tanner, John J

Cautionary Tale of Using Tris(alkyl)phosphine Reducing Agents with NAD(+)-Dependent Enzymes

使用三(烷基)膦还原剂处理NAD(+)依赖性酶的警示案例

Patel, Sagar M; Smith, Thomas G; Morton, Martha; Stiers, Kyle M; Seravalli, Javier; Mayclin, Stephen J; Edwards, Thomas E; Tanner, John J; Becker, Donald F

Asp263 missense variants perturb the active site of human phosphoglucomutase 1

Asp263错义变异会扰乱人磷酸葡萄糖变位酶1的活性位点

Stiers, Kyle M; Graham, Abigail C; Kain, Bailee N; Beamer, Lesa J

Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily

α-D-磷酸己糖变位酶超家族的生物学、机制和结构

Stiers, Kyle M; Muenks, Andrew G; Beamer, Lesa J