日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Randomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX)

慢性粒细胞白血病酪氨酸激酶抑制剂停药后,罗培干扰素α-2b与监测的随机3期试验(ENDURE/CML-IX)

Burchert, Andreas; Nicolini, Franck E; le Coutre, Philipp; Saussele, Susanne; Hochhaus, Andreas; Tuere, Evin; Metzelder, Stephan K; Pauck, Kim; Garn, Holger; Raifer, Hartmann; Huber, Magdalena; Gattermann, Norbert; Crysandt, Martina; Schafhausen, Philippe; Bormann, Matthias; Radsak, Markus P; Guerci-Bresler, Agnès; Illmer, Thomas; Goebeler, Maria E; Herhaus, Peter; Teichmann, Lino L; Franke, Georg-Nikolaus; Lang, Fabian; Krause, Stefan W; Möhle, Robert; Klausmann, Martine; Stegelmann, Frank; Lutz, Christoph; Etienne, Gabriel; Stoltefuß, Andrea; Göthert, Joachim R; Ernst, Thomas; Abu-Samra, Maisun; Höffkes, Heinz-Gert; Neubauer, Andreas; Wang, Ying; Weiland, Paul; Otto, Clara; Kiessler, Lea; Weber, Theresa; Kroning, Lea; Nist, Andrea; Stiewe, Thorsten; Hehlmann, Rüdiger; Aminossadati, Behnaz; Wittenberg, Michael; Winterstein, Kerstin; Oellerich, Thomas; Lechner, Marcus; Pfirrmann, Markus; Schade-Brittinger, Carmen; Klemm, Paul; Michel, Christian

mTOR-driven autophagy suppression defines metabolic vulnerability in CDK4/6 inhibitor-resistant HR(+)/HER2(-) breast cancer.

mTOR 驱动的自噬抑制定义了 CDK4/6 抑制剂耐药的 HR(+)/HER2(-) 乳腺癌的代谢脆弱性。

von Wichert Luise, Stroh Alina, Witt Marie, Wanzel Michael, Mernberger Marco, Griewing Sebastian, Wündisch Thomas, Pfitzner Berit M, Teply-Szymanski Julia, Litmeyer Anne-Sophie, Denkert Carsten, Wagner Uwe, Stiewe Thorsten, Gremke Niklas

Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt.

使用小分子稳定剂rezatapopt靶向p53癌症突变体Y220C、Y220N和Y220S。

Mavridi Danai, Funk Julianne S, Balourdas Dimitrios-Ilias, Krämer Andreas, Khan Tareque Raysa, Timofeev Oleg, Spencer John, Stiewe Thorsten, Joerger Andreas C

Divergent CD45(+) immune landscapes shape the lung tumor microenvironment

不同的CD45(+)免疫微环境塑造了肺肿瘤微环境

Dizdarević, Selma; Wiegandt, René; Weigert, Andreas; Stiewe, Thorsten; Eul, Bastian; Guenther, Stefan; Grimminger, Friedrich; Seeger, Werner; Pullamsetti, Soni Savai; Looso, Mario; Turkowski, Kati; Savai, Rajkumar

Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance

低外显率的TP53变异体主要为功能减弱型:这是一个被低估但具有重要临床意义的问题。

Rodriguez, Lea; Leroy, Bernard; Toledo, Franck; Funk, Julianne Susanne; Stiewe, Thorsten; Baliakas, Panagiotis; Delhommeau, François; Soussi, Thierry

Leptin-dependent fat accumulation triggers autophagy in metabolic dysfunction-associated steatohepatitis model.

瘦素依赖性脂肪积累可触发代谢功能障碍相关脂肪性肝炎模型中的自噬。

Polte Sophia C H, Matono Tomomitsu, Okamoto Kinya, Koda Masahiko, Ebrahimifard Ali, Wanzel Michael, Stiewe Thorsten, Wissniowski Thaddeus T, Matrood Sami, Di Fazio Pietro

Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs.

利用代谢药物靶向治疗乳腺癌中的PI3K抑制剂耐药性

Gremke Niklas, Besong Isabelle, Stroh Alina, von Wichert Luise, Witt Marie, Elmshäuser Sabrina, Wanzel Michael, Fromm Martin F, Taudte R Verena, Schmatloch Sabine, Karn Thomas, Reinisch Mattea, Hirmas Nader, Loibl Sibylle, Wündisch Thomas, Litmeyer Anne-Sophie, Jank Paul, Denkert Carsten, Griewing Sebastian, Wagner Uwe, Stiewe Thorsten

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.

深度 CRISPR 诱变表征了 TP53 突变的功能多样性

Funk Julianne S, Klimovich Maria, Drangenstein Daniel, Pielhoop Ole, Hunold Pascal, Borowek Anna, Noeparast Maxim, Pavlakis Evangelos, Neumann Michelle, Balourdas Dimitrios-Ilias, Kochhan Katharina, Merle Nastasja, Bullwinkel Imke, Wanzel Michael, Elmshäuser Sabrina, Teply-Szymanski Julia, Nist Andrea, Procida Tara, Bartkuhn Marek, Humpert Katharina, Mernberger Marco, Savai Rajkumar, Soussi Thierry, Joerger Andreas C, Stiewe Thorsten

TP53: the unluckiest of genes?

TP53:最不幸的基因?

Joerger, Andreas C; Stiewe, Thorsten; Soussi, Thierry

A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages

人类巨噬细胞中病原体敏感的lncRNA网络可搜索图谱

Nils Schmerer ,Harshavardhan Janga ,Michelle Aillaud ,Janina Hoffmann ,Marina Aznaourova ,Sarah Wende ,Henrike Steding ,Luke D Halder ,Michael Uhl ,Fabian Boldt ,Thorsten Stiewe ,Andrea Nist ,Lukas Jerrentrup ,Andreas Kirschbaum ,Clemens Ruppert ,Oliver Rossbach ,Evgenia Ntini ,Annalisa Marsico ,Chanil Valasarajan ,Rolf Backofen ,Uwe Linne ,Soni S Pullamsetti ,Bernd Schmeck ,Leon N Schulte