日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

BRAF(V600E) patient derived colon cancer organoids identify biomarkers of response to EGFR and BRAF inhibition and replicate clinical data

BRAF(V600E)患者来源的结肠癌类器官可识别EGFR和BRAF抑制剂疗效的生物标志物，并能重现临床数据。

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-026-03699-2
Kotarac, Anna; Osumi, Hiroki; Malt, Alexander; Alp, Keziban Merve; Jarosch, Armin; Werner, Johannes; Benary, Manuela; Neumann, Christopher C M; Yao, Ryoji; Mertins, Philipp; Eils, Roland; Beule, Dieter; Sers, Christine; Keilholz, Ulrich; Ishaque, Naveed; Stintzing, Sebastian; Vecchione, Loredana
肿瘤
肠癌
肿瘤免疫
EGF
BRAF
EGFR
3D/类器官
发表日期：2026
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Impact of culture dimensionality and matrix composition on morphology, phenotype and drug response in pancreatic cancer models

培养维度和基质组成对胰腺癌模型形态、表型和药物反应的影响

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-026-47856-1
Doelvers, Florian; Wansch, Katharina; Kuehn, Anna; Dragomir, Mihnea P; Janik, Tobias; Joosten, Maria; Hilfenhaus, Georg; Vecchione, Loredana; Felsenstein, Matthäus; Ma, Dou; Lerchbaumer, Markus; Jürgensen, Christian; Bahra, Marcus; Duwe, Gregor; Stintzing, Sebastian; Keilholz, Ulrich; Pelzer, Uwe; Neumann, Christopher C M
胰腺癌
肿瘤
肿瘤免疫
发表日期：2026
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PROTECTOR / FIRE‑10: study protocol for a prospective, randomized, open-label, multicenter phase III trial to investigate the efficacy of preoperative systemic therapy in advanced colon cancer

PROTECTOR / FIRE-10：一项前瞻性、随机、开放标签、多中心 III 期临床试验的研究方案，旨在研究术前全身治疗对晚期结肠癌的疗效

期刊:BMC Cancer
影响因子:3.4
doi:10.1186/s12885-026-15682-3
Siegel, Robert; Dittrich, Luca; Plewe, Julius; Denecke, Timm; Leonhardi, Jakob; Tannapfel, Andrea; Reinacher-Schick, Anke; Raschzok, Nathanael; Sauer, Igor Maximilian; Lauscher, Johannes; Lorenzen, Sylvie; Götze, Thorsten; Jelas, Ivan; Stahler, Arndt; Kurreck, Annika; Ballhausen, Alexej; Ostendorf, Benjamin Nils; Haase, Oliver; Pratschke, Johann; Stintzing, Sebastian; Modest, Dominik Paul
肿瘤
肠癌
肿瘤免疫
TEC
发表日期：2026
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Identifying Factors of Organoid Establishment in Pancreatic Cancer: A Prospective Observational Study

胰腺癌类器官形成因素的识别：一项前瞻性观察研究

期刊:Cancer Medicine
影响因子:3.1
doi:10.1002/cam4.71490
Wansch, Katharina; Schneider, François; Dölvers, Florian; Kühn, Anna; Dragomir, Mihnea P; Joosten, Maria; Hilfenhaus, Georg; Vecchione, Loredana; Felsenstein, Matthäus; Lerchbaumer, Markus; Jürgensen, Christian; Bahra, Marcus; Duwe, Gregor; Schäfer, Reinhold; Stintzing, Sebastian; Keilholz, Ulrich; Neumann, Christopher C M; Pelzer, Uwe
肿瘤
胰腺癌
肿瘤免疫
3D/类器官
发育与干细胞
发表日期：2026
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Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition.

通过 p53 激活或细胞周期抑制来中断 HSF1-HSP90 轴，从而增强结直肠癌的治疗效果。

期刊:Cell Death and Differentiation
影响因子:15.4
doi:10.1038/s41418-025-01502-x
Isermann Tamara, Schneider Kim Lucia, Wegwitz Florian, De Oliveira Tiago, Conradi Lena-Christin, Volk Valery, Feuerhake Friedrich, Papke Björn, Stintzing Sebastian, Mundt Bettina, Kühnel Florian, Moll Ute M, Schulz-Heddergott Ramona
肠癌
细胞生物学
P53
HSF1
HSP90
发表日期：2025
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Panitumumab plus 5-fluorouracil and folinic acid or 5-fluorouracil and folinic acid alone as maintenance therapy in RAS wild-type metastatic colorectal cancer (PanaMa, AIO KRK 0212): final efficacy analysis of a randomised, open-label, phase 2 trial

帕尼单抗联合 5-氟尿嘧啶和亚叶酸钙或单独使用 5-氟尿嘧啶和亚叶酸钙作为 RAS 野生型转移性结直肠癌的维持治疗（PanaMa，AIO KRK 0212）：一项随机、开放标签、II 期试验的最终疗效分析

期刊:EClinicalMedicine
影响因子:10
doi:10.1016/j.eclinm.2024.103004
Stahler, Arndt; Karthaus, Meinolf; Fruehauf, Stefan; Graeven, Ullrich; Müller, Lothar; Fischer von Weikersthal, Ludwig; Caca, Karel; Goekkurt, Eray; Ballhausen, Alexej; Sommerhäuser, Greta; Alig, Annabel H S; Held, Swantje; Jarosch, Armin; Horst, David; Reinacher-Schick, Anke; Kasper, Stefan; Heinemann, Volker; Stintzing, Sebastian; Trarbach, Tanja; Modest, Dominik P
RAS
肿瘤
肠癌
肿瘤免疫
发表日期：2025
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Quality-adjusted survival in patients with metastatic colorectal cancer treated with fruquintinib plus best supportive care: results from FRESCO-2

接受呋喹替尼联合最佳支持治疗的转移性结直肠癌患者的质量调整生存期：FRESCO-2 研究结果

期刊:ESMO Open
影响因子:8.3
doi:10.1016/j.esmoop.2025.104297
Stintzing, S; Tabernero, J; Satoh, T; Dasari, A; Lonardi, S; Eng, C; Garcia-Carbonero, R; Elez, E; Yoshino, T; Sobrero, A F; Yao, J C; Kasper, S; Arnold, D; Basic, E; Granold, M; Petschulies, M; Wu, L; Chung, Y-C; Chen, L; Yang, Z; Van Cutsem, E
肿瘤
肠癌
肿瘤免疫
发表日期：2025
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Pharmacogenetic Testing for DPD Deficiency: Four and a Half Years' Experience in a Large German Laboratory

DPD缺乏症的药物遗传学检测：一家大型德国实验室四年半的经验

期刊:Deutsches Arzteblatt International
影响因子:7.1
doi:10.3238/arztebl.m2025.0092
Pretzsch, Thomas; Schwab, Matthias; Blau, Olga; Wörmann, Bernhard; Stintzing, Sebastian; Bullinger, Lars; Burmeister, Thomas
发表日期：2025
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Outcomes for FOLFIRI plus bevacizumab or cetuximab in patients treated with oxaliplatin-based adjuvant therapy: A combined analysis of FIRE-3 and CALGB/SWOG 80405 (Alliance)

FOLFIRI 联合贝伐单抗或西妥昔单抗治疗奥沙利铂辅助治疗患者的疗效：FIRE-3 和 CALGB/SWOG 80405 (Alliance) 的联合分析

期刊:European Journal of Cancer
影响因子:7.1
doi:10.1016/j.ejca.2025.115694
Battaglin, Francesca; O'Neil, Bert H; Stintzing, Sebastian; Ou, Fang-Shu; Zemla, Tyler J; Niedzwiecki, Donna; Innocenti, Federico; Hochster, Howard S; von Weikersthal, Ludwig Fischer; Decker, Thomas; Kiani, Alexander; Vehling-Kaiser, Ursula; Heintges, Tobias; Lerchenmüller, Christian; Weiss, Lena; Heinrich, Kathrin; Goldberg, Richard M; Mayer, Robert J; Schilsky, Richard L; Blanke, Charles D; Venook, Alan P; Lenz, Heinz-Josef; Heinemann, Volker
发表日期：2025
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Primary tumor sidedness and negative hyperselection to modulate anti-EGFR-based maintenance strategies in patients with RAS wild-type metastatic colorectal cancer: individual patient data pooled analysis of two randomized clinical trials

原发肿瘤侧别和负性超选择对RAS野生型转移性结直肠癌患者抗EGFR维持治疗策略的影响：两项随机临床试验的个体患者数据汇总分析

期刊:British Journal of Cancer
影响因子:6.8
doi:10.1038/s41416-025-03164-5
Ballhausen, Alexej; Morano, Federica; Stahler, Arndt; Lonardi, Sara; Kind, Andreas Jay; Cremolini, Chiara; Swoboda, Susanna; Randon, Giovanni; Horst, David; Prisciandaro, Michele; Alig, Annabel Helga Sophie; Pircher, Chiara Carlotta; Jarosch, Armin; Andena, Paola; Kurreck, Annika; Chiaramonte, Anna Alessandra; Stintzing, Sebastian; Pietrantonio, Filippo; Modest, Dominik Paul; Raimondi, Alessandra
肿瘤
肠癌
肿瘤免疫
EGF
EGFR
RAS
发表日期：2025
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