日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tet2 modulates ER stress responses related to β-cell death and autoimmunity in diabetes

Tet2调节与糖尿病β细胞死亡和自身免疫相关的内质网应激反应

Rui, Jinxiu; Kothari, Madhav; Kursawe, Romy; Barkestani, Mahsa Nouri; Genosar, Romi; Clark, Pamela; Stitzel, Michael L; Herold, Kevan C

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

逆行线粒体信号传导控制着代谢组织的特性和成熟度。

Walker, Emily M; Pearson, Gemma L; Lawlor, Nathan; Stendahl, Ava M; Lietzke, Anne; Sidarala, Vaibhav; Zhu, Jie; Stromer, Tracy; Reck, Emma C; Li, Jin; Levi-D'Ancona, Elena; Pasmooij, Mabelle B; Hubers, Dre L; Renberg, Aaron; Mohamed, Kawthar; Parekh, Vishal S; Zhang, Irina X; Thompson, Benjamin; Zhang, Deqiang; Ware, Sarah A; Haataja, Leena; Qi, Nathan; Parker, Stephen C J; Arvan, Peter; Yin, Lei; Kaufman, Brett A; Satin, Leslie S; Sussel, Lori; Stitzel, Michael L; Soleimanpour, Scott A

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes.

LONP1 对线粒体蛋白折叠的调控为 2 型糖尿病中 β 细胞功能衰竭提供了见解

Li Jin, Deng Yamei, Gasser Marie, Zhu Jie, Walker Emily M, Sidarala Vaibhav, Reck Emma C, Hubers Dre L, Pasmooij Mabelle B, Shin Chun-Shik, Bandesh Khushdeep, Motakis Eftyhmios, Nargund Siddhi, Kursawe Romy, Basrur Venkatesha, Nesvizhskii Alexey I, Stitzel Michael L, Chan David C, Rutter Guy A, Soleimanpour Scott A

From Human to Mouse and Back Again: Genetic and Genomic Ta(i)les of Islet Dysfunction in Type 2 Diabetes

从人类到小鼠再回到人类:2型糖尿病胰岛功能障碍的遗传和基因组故事

Kursawe, Romy; Bandesh, Khushdeep; Krishnan, Sai Nivedita; Liu, Kevin S; Bhuiyan, Redwan M; Stitzel, Michael L

Single-cell decoding of human islet cell type-specific alterations in type 2 diabetes reveals converging genetic- and state-driven β -cell gene expression defects

对2型糖尿病中人类胰岛细胞类型特异性改变的单细胞解码揭示了遗传和状态驱动的β细胞基因表达缺陷的汇聚。

Bandesh, Khushdeep; Motakis, Efthymios; Nargund, Siddhi; Kursawe, Romy; Selvam, Vijay; Bhuiyan, Redwan M; Eryilmaz, Giray Naim; Krishnan, Sai Nivedita; Spracklen, Cassandra N; Ucar, Duygu; Stitzel, Michael L

Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits

利用深度学习对胰岛增强子进行建模,可识别与2型糖尿病和血糖特征相关的基因位点上的候选致病变异。

Hudaiberdiev, Sanjarbek; Taylor, D Leland; Song, Wei; Narisu, Narisu; Bhuiyan, Redwan M; Taylor, Henry J; Tang, Xuming; Yan, Tingfen; Swift, Amy J; Bonnycastle, Lori L; Consortium, Diamante; Chen, Shuibing; Stitzel, Michael L; Erdos, Michael R; Ovcharenko, Ivan; Collins, Francis S

AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

AMULET:一种基于读取计数的新型方法,可从单细胞核ATAC-seq数据中有效检测多重突变体。

Thibodeau, Asa; Eroglu, Alper; McGinnis, Christopher S; Lawlor, Nathan; Nehar-Belaid, Djamel; Kursawe, Romy; Marches, Radu; Conrad, Daniel N; Kuchel, George A; Gartner, Zev J; Banchereau, Jacques; Stitzel, Michael L; Cicek, A Ercument; Ucar, Duygu

A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures

人类胰岛转录起始位点图谱揭示功能性调控特征

Varshney, Arushi; Kyono, Yasuhiro; Elangovan, Venkateswaran Ramamoorthi; Wang, Collin; Erdos, Michael R; Narisu, Narisu; Albanus, Ricardo D'Oliveira; Orchard, Peter; Stitzel, Michael L; Collins, Francis S; Kitzman, Jacob O; Parker, Stephen C J

CoRE-ATAC: A deep learning model for the functional classification of regulatory elements from single cell and bulk ATAC-seq data

CoRE-ATAC:一种用于从单细胞和批量ATAC-seq数据中对调控元件进行功能分类的深度学习模型

Thibodeau, Asa; Khetan, Shubham; Eroglu, Alper; Tewhey, Ryan; Stitzel, Michael L; Ucar, Duygu

From GWAS Association to Function: Candidate Gene Screening Within Insulin Resistance-Associated Genomic Loci Using a Preadipocyte Differentiation Model

从全基因组关联分析到功能:利用前脂肪细胞分化模型筛选胰岛素抵抗相关基因组位点的候选基因

Ladha, Feria A; Stitzel, Michael L; Hinson, J Travis