日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Population Pharmacokinetics of Atogepant for the Prevention of Migraine

阿托格泮预防偏头痛的群体药代动力学

Schlachter, Louisa; Stodtmann, Sven; Voelkner, Alexander; Jonsson, Fredrik; Lagraauw, Hendrik Maxime; Boinpally, Ramesh R

Predictive AI in Clinical Pharmacology: A Call to Action to Develop Robust Benchmarking Practices

临床药理学中的预测性人工智能:呼吁建立稳健的基准测试实践

Ponce-Bobadilla, Ana Victoria; Bräm, Dominic; Farnoud, Ali; Fröhlich, Holger; Janssen, Alexander; Korsbo, Niklas; Lindauer, Klaus; Raimúndez, Elba; Saini, Anuraag; Stodtmann, Sven; Valderrama, Diego; Balling, Kristoffer Winther; Knöchel, Jane; Mensing, Sven

Exposure-Response Modeling of Monthly Migraine Days for Efficacy of Atogepant in Patients With Episodic or Chronic Migraine

基于每月偏头痛天数的暴露-反应模型评估阿托格泮治疗发作性或慢性偏头痛患者的疗效

Schlachter, Louisa; Beck, Denise; Boinpally, Ramesh R; Stodtmann, Sven

Use of Model-Based Meta-Analysis to Inform the Design of Early Clinical Trials of Anti-Amyloid Beta Therapies in Alzheimer's Disease

利用基于模型的荟萃分析指导阿尔茨海默病抗β-淀粉样蛋白疗法的早期临床试验设计

Bachhav, Sagar S; Ponce-Bobadilla, Ana Victoria; Clausznitzer, Diana; Stodtmann, Sven; Xiong, Hao

Model-Informed Paradigm in Drug Development-An End-To-End Case Study From Upadacitinib Development

基于模型的药物研发范式——以乌帕替尼研发为例的端到端案例研究

Bhatnagar, Sumit; Stodtmann, Sven; Qian, Yuli; Marroum, Patrick; Liu, Wei; Mohamed, Mohamed-Eslam F

Integrating machine learning with pharmacokinetic models: Benefits of scientific machine learning in adding neural networks components to existing PK models

将机器学习与药代动力学模型相结合:在现有药代动力学模型中添加神经网络组件,发挥科学机器学习的优势

Valderrama, Diego; Ponce-Bobadilla, Ana Victoria; Mensing, Sven; Fröhlich, Holger; Stodtmann, Sven

Practical guide to SHAP analysis: Explaining supervised machine learning model predictions in drug development

SHAP 分析实用指南:解释药物研发中监督式机器学习模型的预测

Ponce-Bobadilla, Ana Victoria; Schmitt, Vanessa; Maier, Corinna S; Mensing, Sven; Stodtmann, Sven

Population pharmacokinetics and exposure-response analyses for efficacy and safety of upadacitinib in patients with axial spondyloarthritis

针对中轴型脊柱关节炎患者,对乌帕替尼进行群体药代动力学和暴露-反应分析,以评估其疗效和安全性

Bhatnagar, Sumit; Eckert, Doerthe; Stodtmann, Sven; Song, In-Ho; Wung, Peter; Liu, Wei; Mohamed, Mohamed-Eslam F

Upadacitinib Population Pharmacokinetics and Exposure-Response Relationships in Ulcerative Colitis Patients

乌帕替尼在溃疡性结肠炎患者中的群体药代动力学和暴露-反应关系

Ponce-Bobadilla, Ana Victoria; Stodtmann, Sven; Eckert, Doerthe; Zhou, Wen; Liu, Wei; Mohamed, Mohamed-Eslam F

Validation of a quantitative systems pharmacology model of calcium homeostasis using elagolix Phase 3 clinical trial data in women with endometriosis

利用elagolix治疗子宫内膜异位症女性的3期临床试验数据验证钙稳态定量系统药理学模型

Stodtmann, Sven; Nader, Ahmed; Polepally, Akshanth R; Suleiman, Ahmed A; Winzenborg, Insa; Noertersheuser, Peter; Ng, Juki; Mostafa, Nael M; Shebley, Mohamad