日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer

UXS1 的缺失选择性地消耗嘧啶并诱导 KEAP1 突变型肺癌中的复制应激

Gebru, Melat T; Hoffman, Timothy E; Boudreau, Aaron; Vu, Ngoc; Han, Fei; Wang, Putianqi; Folk, Eddie; Wu, Xiumin; Newton, James; Foster-Duke, Kelly D; Gajda, Jessica; Villa, Sammy; Yang, Nianxin; Sandoval, Celeste M; Grant, Christian; Wildeboer, Samatha E; Buck, Wayne R; Hickson, Jonathan A; Firestone, Ari J; Kort, Michael; Bennett, Bryson D; Shotwell, J Brad; Wilson, Noel S; Stokoe, David

BiDAC-dependent degradation of plasma membrane proteins by the endolysosomal system.

BiDAC依赖性内溶酶体系统降解质膜蛋白

Villa Sammy, Jafri Qumber, Lazzari-Dean Julia R, Sangha Manjot, Olsson Niclas, Lefebvre Austin E Y T, Fitzgerald Mark E, Jackson Katrina, Chen Zhenghao, Feng Brian Y, Nile Aaron H, Stokoe David, Bersuker Kirill

Inhibition of Aurora Kinase Induces Endogenous Retroelements to Induce a Type I/III IFN Response via RIG-I

抑制极光激酶可诱导内源性逆转录元件通过RIG-I诱导I/III型干扰素反应。

Choy, Lisa; Norris, Stephen; Wu, Xiumin; Kolumam, Ganesh; Firestone, Ari; Settleman, Jeffrey; Stokoe, David

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

小分子配体与Ras蛋白的特定口袋结合,抑制SOS介导的核苷酸交换活性。

Maurer, Till; Garrenton, Lindsay S; Oh, Angela; Pitts, Keith; Anderson, Daniel J; Skelton, Nicholas J; Fauber, Benjamin P; Pan, Borlan; Malek, Shiva; Stokoe, David; Ludlam, Mary J C; Bowman, Krista K; Wu, Jiansheng; Giannetti, Anthony M; Starovasnik, Melissa A; Mellman, Ira; Jackson, Peter K; Rudolph, Joachim; Wang, Weiru; Fang, Guowei

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers

PH激酶结构域相互作用的破坏会导致人类癌症中AKT的致癌激活。

Parikh, Chaitali; Janakiraman, Vasantharajan; Wu, Wen-I; Foo, Catherine K; Kljavin, Noelyn M; Chaudhuri, Subhra; Stawiski, Eric; Lee, Brian; Lin, Jie; Li, Hong; Lorenzo, Maria N; Yuan, Wenlin; Guillory, Joseph; Jackson, Marlena; Rondon, Jesus; Franke, Yvonne; Bowman, Krista K; Sagolla, Meredith; Stinson, Jeremy; Wu, Thomas D; Wu, Jiansheng; Stokoe, David; Stern, Howard M; Brandhuber, Barbara J; Lin, Kui; Skelton, Nicholas J; Seshagiri, Somasekar

DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression

DNA高甲基化谱与胶质瘤亚型及EZH2和IGFBP2 mRNA表达相关

Zheng, Shichun; Houseman, E Andres; Morrison, Zachary; Wrensch, Margaret R; Patoka, Joseph S; Ramos, Christian; Haas-Kogan, Daphne A; McBride, Sean; Marsit, Carmen J; Christensen, Brock C; Nelson, Heather H; Stokoe, David; Wiemels, Joseph L; Chang, Susan M; Prados, Michael D; Tihan, Tarik; Vandenberg, Scott R; Kelsey, Karl T; Berger, Mitchel S; Wiencke, John K

Zinc finger nucleases as tools to understand and treat human diseases

锌指核酸酶作为理解和治疗人类疾病的工具

Davis, David; Stokoe, David

Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival

PI3K/mTOR通路激活发生于大多数成人低级别胶质瘤中,并可预测患者生存期。

McBride, Sean M; Perez, Daniel A; Polley, Mei-Yin; Vandenberg, Scott R; Smith, Justin S; Zheng, Shichun; Lamborn, Kathleen R; Wiencke, John K; Chang, Susan M; Prados, Michael D; Berger, Mitchel S; Stokoe, David; Haas-Kogan, Daphne A

Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma

一项针对新诊断的多形性胶质母细胞瘤或胶质肉瘤患者,在放射治疗期间及之后使用厄洛替尼联合替莫唑胺的II期研究

Prados, Michael D; Chang, Susan M; Butowski, Nicholas; DeBoer, Rebecca; Parvataneni, Rupa; Carliner, Hannah; Kabuubi, Paul; Ayers-Ringler, Jennifer; Rabbitt, Jane; Page, Margaretta; Fedoroff, Anne; Sneed, Penny K; Berger, Mitchel S; McDermott, Michael W; Parsa, Andrew T; Vandenberg, Scott; James, C David; Lamborn, Kathleen R; Stokoe, David; Haas-Kogan, Daphne A

Converting cancer mutations into therapeutic opportunities

将癌症突变转化为治疗契机

O'Brien, Tom; Stokoe, David