日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement.

小分子 LOXL2 抑制剂 SNT-5382 可减少心脏纤维化,并实现强大的临床靶点结合

Perryman Lara, Findlay Alison, Baskar Jana, Charlton Brett, Foot Jonathan, Hamilton Ross, Hamprecht Dieter, Joshi Amar, Stolp Jessica, Turner Craig, Zahoor Amna, Zhou Wenbin, López Begoña, Ravassa Susana, González Arantxa, Jarolimek Wolfgang

An activity-based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti-fibrotic therapeutic strategies

一种基于活性的生物探针能够区分新型小分子抑制剂和LOXL2抗体,并为抗纤维化治疗策略带来新的希望。

Findlay, Alison; Turner, Craig; Schilter, Heidi; Deodhar, Mandar; Zhou, Wenbin; Perryman, Lara; Foot, Jonathan; Zahoor, Amna; Yao, Yimin; Hamilton, Ross; Brock, Mary; Raso, Christina; Stolp, Jessica; Galati, Marie; Hamprecht, Dieter; Charlton, Brett; Jarolimek, Wolfgang

Hypoxia-inducible factor-1α (HIF-1α) potentiates β-cell survival after islet transplantation of human and mouse islets

缺氧诱导因子-1α (HIF-1α) 可增强人胰岛和鼠胰岛移植后β细胞的存活率。

Stokes, Rebecca A; Cheng, Kim; Deters, Natasha; Lau, Sue Mei; Hawthorne, Wayne J; O'Connell, Philip J; Stolp, Jessica; Grey, Shane; Loudovaris, Thomas; Kay, Thomas W; Thomas, Helen E; Gonzalez, Frank J; Gunton, Jenny E

Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic mice

位于Idd5和Idd9/11糖尿病易感基因位点内的基因会影响非肥胖糖尿病小鼠体内B细胞的致病活性。

Silveira, Pablo A; Chapman, Harold D; Stolp, Jessica; Johnson, Ellis; Cox, S Lewis; Hunter, Kara; Wicker, Linda S; Serreze, David V