日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies

对WD重复结构域5抑制剂的扩展分析揭示了治疗血液系统恶性肿瘤的可行策略

Meyer, Christian T; Smith, Brianna N; Wang, Jing; Teuscher, Kevin B; Grieb, Brian C; Howard, Gregory C; Silver, Alexander J; Lorey, Shelly L; Stott, Gordon M; Moore, William J; Lee, Taekyu; Savona, Michael R; Weissmiller, April M; Liu, Qi; Quaranta, Vito; Fesik, Stephen W; Tansey, William P

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

基于结构的高效WD重复结构域5抑制剂的发现,在临床前动物模型中证实了其疗效和安全性。

Teuscher, Kevin B; Chowdhury, Somenath; Meyers, Kenneth M; Tian, Jianhua; Sai, Jiqing; Van Meveren, Mayme; South, Taylor M; Sensintaffar, John L; Rietz, Tyson A; Goswami, Soumita; Wang, Jing; Grieb, Brian C; Lorey, Shelly L; Howard, Gregory C; Liu, Qi; Moore, William J; Stott, Gordon M; Tansey, William P; Lee, Taekyu; Fesik, Stephen W

Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer

优化基于1,2,4-三唑的p97抑制剂用于癌症治疗

LaPorte, Matthew G; Alverez, Celeste; Chatterley, Alexander; Kovaliov, Marina; Carder, Evan J; Houghton, Michael J; Lim, Chaemin; Miller, Eric R; Samankumara, Lalith P; Liang, Mary; Kerrigan, Kaylan; Yue, Zhizhou; Li, Shan; Tomaino, Francesca; Wang, Feng; Green, Neal; Stott, Gordon M; Srivastava, Apurva; Chou, Tsui-Fen; Wipf, Peter; Huryn, Donna M

Optimization of ether and aniline based inhibitors of lactate dehydrogenase

乳酸脱氢酶醚类和苯胺类抑制剂的优化

Christov, Plamen P; Kim, Kwangho; Jana, Somnath; Romaine, Ian M; Rai, Ganesha; Mott, Bryan T; Allweil, Alexander A; Lamers, Alexander; Brimacombe, Kyle R; Urban, Daniel J; Lee, Tobie D; Hu, Xin; Lukacs, Christine M; Davies, Douglas R; Jadhav, Ajit; Hall, Matthew D; Green, Neal; Moore, William J; Stott, Gordon M; Flint, Andrew J; Maloney, David J; Sulikowski, Gary A; Waterson, Alex G

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.

动态成像显示肿瘤中 LDH 抑制可导致体内代谢快速重编程,并对联合疗法产生敏感性

Oshima Nobu, Ishida Ryo, Kishimoto Shun, Beebe Kristin, Brender Jeffrey R, Yamamoto Kazutoshi, Urban Daniel, Rai Ganesha, Johnson Michelle S, Benavides Gloria, Squadrito Giuseppe L, Crooks Dan, Jackson Joseph, Joshi Abhinav, Mott Bryan T, Shrimp Jonathan H, Moses Michael A, Lee Min-Jung, Yuno Akira, Lee Tobie D, Hu Xin, Anderson Tamara, Kusewitt Donna, Hathaway Helen H, Jadhav Ajit, Picard Didier, Trepel Jane B, Mitchell James B, Stott Gordon M, Moore William, Simeonov Anton, Sklar Larry A, Norenberg Jeffrey P, Linehan W Marston, Maloney David J, Dang Chi V, Waterson Alex G, Hall Matthew, Darley-Usmar Victor M, Krishna Murali C, Neckers Leonard M

Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.

发现和基于结构的强效选择性 WD 重复结构域 5 (WDR5) 抑制剂,该抑制剂含有二氢异喹啉酮双环核心

Tian Jianhua, Teuscher Kevin B, Aho Erin R, Alvarado Joseph R, Mills Jonathan J, Meyers Kenneth M, Gogliotti Rocco D, Han Changho, Macdonald Jonathan D, Sai Jiqing, Shaw J Grace, Sensintaffar John L, Zhao Bin, Rietz Tyson A, Thomas Lance R, Payne William G, Moore William J, Stott Gordon M, Kondo Jumpei, Inoue Masahiro, Coffey Robert J, Tansey William P, Stauffer Shaun R, Lee Taekyu, Fesik Stephen W

Allosteric p97 Inhibitors Can Overcome Resistance to ATP-Competitive p97 Inhibitors for Potential Anticancer Therapy

变构p97抑制剂可克服对ATP竞争性p97抑制剂的耐药性,具有潜在的抗癌治疗价值。

Wang, Feng; Li, Shan; Gan, Taiping; Stott, Gordon M; Flint, Andrew; Chou, Tsui-Fen