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Stover Joshua D, Trone Matthew A R, Weston Jacob, Lewis Christian, Levis Hunter, Farhang Niloofar, Philippi Matthew, Zeidan Michelle, Lawrence Brandon, Bowles Robby D

免疫/内分泌

炎症

发表日期：2024

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pH: A major player in degenerative intervertebral disks

pH值：椎间盘退变的重要因素

期刊:JOR Spine

影响因子:3.9

doi:10.1002/jsp2.70025

Trone, Matthew A R; Stover, Joshua D; Almarza, Alejandro; Bowles, Robert D

发表日期：2024

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Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD-conditioned media-induced mechanical sensitivity

对伤害性神经元中离子通道表达进行多重表观基因组编辑，可消除椎间盘退行性变培养基诱导的机械敏感性。

期刊:JOR Spine

影响因子:3.9

doi:10.1002/jsp2.1253

Stover, Joshua D; Trone, Matthew A; Lawrence, Brandon; Bowles, Robby D

Therapeutic TNF-alpha Delivery After CRISPR Receptor Modulation in the Intervertebral Disc

利用 CRISPR 受体调控技术在椎间盘中递送治疗性 TNF-α

期刊:

影响因子:

doi:10.1101/2023.05.31.542947

Stover, Joshua D; Trone, Matthew A R; Weston, Jacob; Lewis, Christian; Levis, Hunter; Philippi, Matthew; Zeidan, Michelle; Lawrence, Brandon; Bowles, Robby D

Degenerative IVD conditioned media and acidic pH sensitize sensory neurons to cyclic tensile strain

退变性椎间盘的条件培养基和酸性pH值会使感觉神经元对周期性拉伸应变更加敏感。

期刊:Journal of Orthopaedic Research

影响因子:2.3

doi:10.1002/jor.24682

Stover, Joshua D; Lawrence, Brandon; Bowles, Robby D

神经科学

发表日期：2021

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Multiplex Epigenome Editing of Dorsal Root Ganglion Neuron Receptors Abolishes Redundant Interleukin 6, Tumor Necrosis Factor Alpha, and Interleukin 1β Signaling by the Degenerative Intervertebral Disc

背根神经节神经元受体的多重表观基因组编辑可消除退变椎间盘中冗余的白细胞介素 6、肿瘤坏死因子 α 和白细胞介素 1β 信号传导

期刊:Human Gene Therapy

影响因子:4

doi:10.1089/hum.2019.032

Stover, Joshua D; Farhang, Niloofar; Lawrence, Brandon; Bowles, Robby D

Therapeutic CRISPR epigenome editing of inflammatory receptors in the intervertebral disc.

利用 CRISPR 技术对椎间盘中的炎症受体进行表观基因组治疗性编辑

pH: A major player in degenerative intervertebral disks

pH值：椎间盘退变的重要因素

Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD-conditioned media-induced mechanical sensitivity

对伤害性神经元中离子通道表达进行多重表观基因组编辑，可消除椎间盘退行性变培养基诱导的机械敏感性。

Therapeutic TNF-alpha Delivery After CRISPR Receptor Modulation in the Intervertebral Disc

利用 CRISPR 受体调控技术在椎间盘中递送治疗性 TNF-α

Degenerative IVD conditioned media and acidic pH sensitize sensory neurons to cyclic tensile strain

退变性椎间盘的条件培养基和酸性pH值会使感觉神经元对周期性拉伸应变更加敏感。

Multiplex Epigenome Editing of Dorsal Root Ganglion Neuron Receptors Abolishes Redundant Interleukin 6, Tumor Necrosis Factor Alpha, and Interleukin 1β Signaling by the Degenerative Intervertebral Disc

背根神经节神经元受体的多重表观基因组编辑可消除退变椎间盘中冗余的白细胞介素 6、肿瘤坏死因子 α 和白细胞介素 1β 信号传导