Design of Potent Menin-KMT2A Interaction Inhibitors with Improved In Vitro ADME Properties and Reduced hERG Affinity
设计具有改进的体外ADME特性和降低的hERG亲和力的高效Menin-KMT2A相互作用抑制剂
期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.4c00311
Chapsal, Bruno D; Kimbrough, Jennifer R; Bester, Stephanie M; Bergstrom, Alex; Backos, Donald S; Campos, Bismarck; McDonald, Matthew G; Abrahamsen, Rebecca; Allen, Andrew C; Doerner Barbour, Patrick M; Bettendorf, Tanna; Boys, Mark L; Brown, Karin; Chicarelli, Mark J; Cook, Adam W; Crooks, Amy L; Cruz, Cole L; Dahlke, Joshua R; Eide, Alida; Fell, Jay B; Fulton, Jennifer L; Gargus, Matthew; Gaudino, John J; Guarnieri, Anna L; Hansen, Erik P; Holt, Melissa C; Kahn, Dean R; Laird, Ellen R; Larsen, Paul D; Linwood, Rebecca; Martinson, Matthew C; McCown, Joseph; Mejia, Macedonio J; Moreno, David A; Mou, Tung-Chung; Newhouse, Brad; O'Leary, Jacob M; Rodriguez, Martha E; Singh, Anurag; Sinik, Lenka; Strand, Keith A; Touney, Eric E; Wollenberg, Lance A; Wong, Jim; Zhou, Yeyun; Fischer, John P; Allen, Shelley
