日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies

社论:靶向离子通道进行药物发现:高通量筛选技术面临的新挑战

Hernandez, Ciria C; Gimenez, Luis E; Strassmaier, Tim; Rogers, Marc; Taymans, Jean-Marc

There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments

APC 中不含氟:使用生理性无氟溶液进行高通量自动化膜片钳实验

Rapedius, Markus; Obergrussberger, Alison; Humphries, Edward S A; Scholz, Stephanie; Rinke-Weiss, Ilka; Goetze, Tom A; Brinkwirth, Nina; Rotordam, Maria Giustina; Strassmaier, Tim; Randolph, Aaron; Friis, Søren; Liutkute, Aiste; Seibertz, Fitzwilliam; Voigt, Niels; Fertig, Niels

Discovery of Novel Activators of Large-Conductance Calcium-Activated Potassium Channels for the Treatment of Cerebellar Ataxia

发现新型大电导钙激活钾通道激活剂用于治疗小脑共济失调

Srinivasan, Sharan R; Huang, Haoran; Chang, Wei-Chih; Nasburg, Joshua A; Nguyen, Hai M; Strassmaier, Tim; Wulff, Heike; Shakkottai, Vikram G

Voltage-gated potassium channel proteins and stereoselective S-nitroso-l-cysteine signaling

电压门控钾通道蛋白和立体选择性 S-亚硝基-l-半胱氨酸信号传导

Benjamin Gaston, Laura Smith, Jürgen Bosch, James Seckler, Diana Kunze, Janna Kiselar, Nadzeya Marozkina, Craig A Hodges, Patrick Wintrobe, Kellen McGee, Tatiana S Morozkina, Spencer T Burton, Tristan Lewis, Timothy Strassmaier, Paulina Getsy, James N Bates, Stephen J Lewis0

Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.

药物对重组细胞中人类心脏电流影响的自动膜片钳评估的跨站点和跨平台变异性

Kramer James, Himmel Herbert M, Lindqvist Anders, Stoelzle-Feix Sonja, Chaudhary Khuram W, Li Dingzhou, Bohme Georg Andrees, Bridgland-Taylor Matthew, Hebeisen Simon, Fan Jingsong, Renganathan Muthukrishnan, Imredy John, Humphries Edward S A, Brinkwirth Nina, Strassmaier Tim, Ohtsuki Atsushi, Danker Timm, Vanoye Carlos, Polonchuk Liudmila, Fermini Bernard, Pierson Jennifer Beck, Gintant Gary

Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961]

对“评估 hERG 阻滞效力的系统策略及其在新的心脏安全范式中的意义”的更正[毒理学和应用药理学卷 394C (2020) 114961]

Ridder, Bradley J; Leishman, Derek J; Bridgland-Taylor, Matthew; Samieegohar, Mohammadreza; Han, Xiaomei; Wu, Wendy W; Randolph, Aaron; Tran, Phu; Sheng, Jiansong; Danker, Timm; Lindqvist, Anders; Konrad, Daniel; Hebeisen, Simon; Polonchuk, Liudmila; Gissinger, Evgenia; Renganathan, Muthukrishnan; Koci, Bryan; Wei, Haiyang; Fan, Jingsong; Levesque, Paul; Kwagh, Jae; Imredy, John; Zhai, Jin; Rogers, Marc; Humphries, Edward; Kirby, Robert; Stoelzle-Feix, Sonja; Brinkwirth, Nina; Rotordam, Maria Giustina; Becker, Nadine; Friis, Søren; Rapedius, Markus; Goetze, Tom A; Strassmaier, Tim; Okeyo, George; Kramer, James; Kuryshev, Yuri; Wu, Caiyun; Himmel, Herbert; Mirams, Gary R; Strauss, David G; Bardenet, Remi; Li, Zhihua

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.

评估 hERG 阻滞效力的系统策略及其在新心脏安全范式中的意义

Ridder Bradley J, Leishman Derek J, Bridgland-Taylor Matthew, Samieegohar Mohammadreza, Han Xiaomei, Wu Wendy W, Randolph Aaron, Tran Phu, Sheng Jiansong, Danker Timm, Lindqvist Anders, Konrad Daniel, Hebeisen Simon, Polonchuk Liudmila, Gissinger Evgenia, Renganathan Muthukrishnan, Koci Bryan, Wei Haiyang, Fan Jingsong, Levesque Paul, Kwagh Jae, Imredy John, Zhai Jin, Rogers Marc, Humphries Edward, Kirby Robert, Stoelzle-Feix Sonja, Brinkwirth Nina, Rotordam Maria Giustina, Becker Nadine, Friis Søren, Rapedius Markus, Goetze Tom A, Strassmaier Tim, Okeyo George, Kramer James, Kuryshev Yuri, Wu Caiyun, Himmel Herbert, Mirams Gary R, Strauss David G, Bardenet Rémi, Li Zhihua

Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

用强效的TRPC4和TRPC5抑制剂HC-070进行治疗,可使小鼠产生抗焦虑和抗抑郁作用。

Just, Stefan; Chenard, Bertrand L; Ceci, Angelo; Strassmaier, Timothy; Chong, Jayhong A; Blair, Nathaniel T; Gallaschun, Randall J; Del Camino, Donato; Cantin, Susan; D'Amours, Marc; Eickmeier, Christian; Fanger, Christopher M; Hecker, Carsten; Hessler, David P; Hengerer, Bastian; Kroker, Katja S; Malekiani, Sam; Mihalek, Robert; McLaughlin, Joseph; Rast, Georg; Witek, JoAnn; Sauer, Achim; Pryce, Christopher R; Moran, Magdalene M

Block of cyclic nucleotide-gated channels by tetracaine derivatives: role of apolar interactions at two distinct locations

丁卡因衍生物对环核苷酸门控通道的阻断:非极性相互作用在两个不同位置的作用

Strassmaier, Timothy; Kirk, Sarah R; Banerji, Tapasree; Karpen, Jeffrey W

Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity

小电导钙激活钾通道2型(SK2)调节海马体的学习、记忆和突触可塑性

Hammond, Rebecca S; Bond, Chris T; Strassmaier, Timothy; Ngo-Anh, Thu Jennifer; Adelman, John P; Maylie, James; Stackman, Robert W