日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high-grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models

在临床前模型中,通过mRNA脂质体靶向激活新型肿瘤抑制因子DAPK1(p53的上游调节因子)可降低高级别浆液性卵巢癌的细胞活力并增强药物敏感性。

Raab, Monika; Győrffy, Balázs; Peña-Llopis, Samuel; Fietz, Daniela; Kressin, Monika; Kolaric, Margareta; Ebert, Matthias; Gasimli, Khayal; Becker, Sven; Sanhaji, Mourad; Strebhardt, Klaus

Structural regulation of PLK1 activity: implications for cell cycle function and drug discovery

PLK1活性的结构调控:对细胞周期功能和药物发现的意义

Chapagai, Danda; Strebhardt, Klaus; Wyatt, Michael D; McInnes, Campbell

Truncated DAPK Variants Restore Tumor Suppressor Activity and Synergize with Standard Therapies in High-Grade Serous Ovarian Cancer.

截短的 DAPK 变体可恢复肿瘤抑制活性,并与高级别浆液性卵巢癌的标准疗法产生协同作用

Raab Monika, Gasimli Khayal, Győrffy Balázs, Peña-Llopis Samuel, Becker Sven, Sanhaji Mourad, Strebhardt Klaus

Correction: A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1

更正:PLK1 的酶活性激活和核转位受二聚化依赖机制调控。

Raab, Monika; Matthess, Yves; Raab, Christopher A; Gutfreund, Niklas; Dötsch, Volker; Becker, Sven; Sanhaji, Mourad; Strebhardt, Klaus

Correction: The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer

更正:Caspase-8 在宫颈癌中负调控 CDK9 介导的 RNA 聚合酶 II Ser2 磷酸化的非凋亡功能

Mandal, Ranadip; Raab, Monika; Rödel, Franz; Krämer, Andrea; Kostova, Izabela; Peña-Llopis, Samuel; Medici, Gioele; Häupl, Björn; Oellerich, Thomas; Gasimli, Khayal; Sanhaji, Mourad; Becker, Sven; Strebhardt, Klaus

Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 Inhibitors

利用小分子BRD4和CDK9抑制剂的组合对缺乏Caspase-8表达的高级别浆液性卵巢癌细胞的化疗药物产生协同增敏作用

Gasimli, Khayal; Raab, Monika; Mandal, Ranadip; Krämer, Andrea; Peña-Llopis, Samuel; Tahmasbi Rad, Morva; Becker, Sven; Strebhardt, Klaus; Sanhaji, Mourad

The role of caspase-8 in the tumor microenvironment of ovarian cancer

caspase-8在卵巢癌肿瘤微环境中的作用

Kostova, Izabela; Mandal, Ranadip; Becker, Sven; Strebhardt, Klaus

Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer

预测子宫颈癌预后和治疗反应的分子标志物

Fleischmann, Maximilian; Chatzikonstantinou, Georgios; Fokas, Emmanouil; Wichmann, Jörn; Christiansen, Hans; Strebhardt, Klaus; Rödel, Claus; Tselis, Nikolaos; Rödel, Franz

The Prognostic Relevance of the Proliferation Markers Ki-67 and Plk1 in Early-Stage Ovarian Cancer Patients With Serous, Low-Grade Carcinoma Based on mRNA and Protein Expression

基于mRNA和蛋白表达的增殖标志物Ki-67和Plk1在早期浆液性低级别卵巢癌患者中的预后意义

Rödel, Franz; Zhou, Shengtao; Győrffy, Balász; Raab, Monika; Sanhaji, Mourad; Mandal, Ranadip; Martin, Daniel; Becker, Sven; Strebhardt, Klaus

Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells.

免疫接头蛋白 SKAP1 为 Polo 样激酶 1 (PLK1) 提供支架,以实现 T 细胞的最佳细胞周期

Raab Monika, Strebhardt Klaus, Rudd Christopher E