日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan

利用siRNA-脂质纳米颗粒沉默PAI-1可降低血栓形成并延长寿命,而PAI-1的年龄相关性增加则可减少血栓形成并延长寿命。

Ferraresso, Francesca; Skaer, Chad W; Wei, Zimu; Paul, Manoj; Hur, Woosuk Steve; Yu, Hongyin; Seadler, Monica; Chen, Taylor H Y; Dai, Wen; Lapointe, Catherine; Ketelboeter, Laura M; Lund, Hayley; Rodriguez, Geoffrey G; Juang, Lih Jiin; Strilchuk, Amy W; Zhang, Youjie; Cullis, Pieter R; Dyer, Mitchell R; Gerras, Allison L; Shi, Qizhen; Luyendyk, James P; Flick, Matthew J; Kastrup, Christian J

Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery.

利用 Passerini 反应合理设计并模块化合成可生物降解的可电离脂质,用于 mRNA 递送

Xu Yue, Gong Fanglin, Golubovic Alex, Strilchuk Amy, Chen Jingan, Zhou Muye, Dong Songtao, Seto Breanna, Li Bowen

Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency

通过诱导获得性 FXIII-B 缺乏症,导致 FXIII-A 持续耗竭。

Strilchuk, Amy W; Meixner, Scott C; Leung, Jerry; Safikhan, Nooshin S; Kulkarni, Jayesh A; Russell, Hannah M; van der Meel, Roy; Sutherland, Michael R; Owens, A Phillip; Palumbo, Joseph S; Conway, Edward M; Pryzdial, Edward L G; Cullis, Pieter R; Kastrup, Christian J