日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

All-in-one CRISPR/Cas-engineered glucocorticoid-receptor knock-out EBV-gp350-CAR knock-in T cells are potent and resistant to dexamethasone

利用 CRISPR/Cas 技术构建的一体化糖皮质激素受体敲除 EBV-gp350-CAR 敲入 T 细胞具有高效活性且对地塞米松耐药。

Kaeuferle, Theresa; Zwermann, Maximilian; Stoll, Nadine; Ferrada-Ernst, Paulina; Jablonowski, Lena; Zeidler, Reinhard; Willier, Semjon; Stenger, Dana; Yassin, Abdallah; Stripecke, Renata; Feuchtinger, Tobias

Integration of ζ-deficient CARs into the CD3ζ gene conveys potent cytotoxicity in T and NK cells

将缺乏 ζ 亚基的 CAR 整合到 CD3ζ 基因中,可赋予 T 细胞和 NK 细胞强大的细胞毒性。

Kath, Jonas; Franke, Clemens; Drosdek, Vanessa; Du, Weijie; Glaser, Viktor; Fuster-Garcia, Carla; Stein, Maik; Zittel, Tatiana; Schulenberg, Sarah; Porter, Caroline E; Andersch, Lena; Künkele, Annette; Alcaniz, Joshua; Hoffmann, Jens; Abken, Hinrich; Abou-El-Enein, Mohamed; Pruß, Axel; Suzuki, Masataka; Cathomen, Toni; Stripecke, Renata; Volk, Hans-Dieter; Reinke, Petra; Schmueck-Henneresse, Michael; Wagner, Dimitrios L

Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles

缺乏鼠主要组织相容性复合体的鼠的长期人类免疫重建、T细胞发育和免疫反应性:细胞和基因表达谱的验证

Darguzyte, Milita; Antczak, Philipp; Bachurski, Daniel; Hoelker, Patrick; Abedpour, Nima; Gholamipoorfard, Rahil; Schlößer, Hans A; Wennhold, Kerstin; Thelen, Martin; Garcia-Marquez, Maria A; Koenig, Johannes; Schneider, Andreas; Braun, Tobias; Klawonn, Frank; Damrat, Michael; Rahman, Masudur; Kleid, Jan-Malte; Theobald, Sebastian J; Bauer, Eugen; von Kaisenberg, Constantin; Talbot, Steven R; Shultz, Leonard D; Soper, Brian; Stripecke, Renata

GMP development and preclinical validation of CAR-T cells targeting a lytic EBV antigen for therapy of EBV-associated malignancies

针对溶解性 EBV 抗原的 CAR-T 细胞的 GMP 开发和临床前验证,用于治疗 EBV 相关恶性肿瘤

Xi Zhang, Tiaoxia Wang, Xiaona Zhu, Yong Lu, Mingpeng Li, Zhihong Huang, Deping Han, Longzhen Zhang, Yang Wu, Liantao Li, Frank Klawonn, Renata Stripecke

Non-viral TRAC-knocked-in CD19KICAR-T and gp350KICAR-T cells tested against Burkitt lymphomas with type 1 or 2 EBV infection: In vivo cellular dynamics and potency

非病毒TRAC敲入CD19KICAR-T和gp350KICAR-T细胞对抗1型或2型EBV感染的伯基特淋巴瘤的体内细胞动力学和效力

Tobias Braun ,Alina Pruene ,Milita Darguzyte ,Alexander F Vom Stein ,Phuong-Hien Nguyen ,Dimitrios L Wagner ,Jonas Kath ,Alicia Roig-Merino ,Michael Heuser ,Lucas L Riehm ,Andreas Schneider ,Sabine Awerkiew ,Steven R Talbot ,André Bleich ,Constanca Figueiredo ,Martin Bornhäuser ,Renata Stripecke

Fully Human Herpesvirus-Specific Neutralizing IgG Antibodies Generated by EBV Immortalization of Splenocytes-Derived from Immunized Humanized Mice

通过EBV永生化脾细胞(源自免疫人源化小鼠)产生的全人源疱疹病毒特异性中和IgG抗体

Sebastian J Theobald ,Elena Fiestas ,Andreas Schneider ,Benjamin Ostermann ,Simon Danisch ,Constantin von Kaisenberg ,Jan Rybniker ,Wolfgang Hammerschmidt ,Reinhard Zeidler ,Renata Stripecke

Review: Sustainable Clinical Development of CAR-T Cells - Switching From Viral Transduction Towards CRISPR-Cas Gene Editing

综述:CAR-T细胞的可持续临床开发——从病毒转导转向CRISPR-Cas基因编辑

Wagner, Dimitrios L; Koehl, Ulrike; Chmielewski, Markus; Scheid, Christoph; Stripecke, Renata

Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET

Delta-24-RGD 是一种溶瘤腺病毒,可提高 AT/RT 和 CNS-PNET 模型中的存活率并促进促炎免疫景观重塑

Marc Garcia-Moure #, Marisol Gonzalez-Huarriz #, Sara Labiano, Elizabeth Guruceaga, Eva Bandres, Marta Zalacain, Lucia Marrodan, Carlos de Andrea, Maria Villalba, Naiara Martinez-Velez, Virginia Laspidea, Montse Puigdelloses, Jaime Gallego Perez-Larraya, Ignacio Iñigo-Marco, Renata Stripecke, Jennif

Correction: Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV

更正:对接种树突状细胞疫苗并获得HCMV保护的人源化小鼠直接克隆的gB特异性人IgG进行抗体库表征和验证

Theobald, Sebastian J; Kreer, Christoph; Khailaie, Sahamoddin; Bonifacius, Agnes; Eiz-Vesper, Britta; Figueiredo, Constanca; Mach, Michael; Backovic, Marija; Ballmaier, Matthias; Koenig, Johannes; Olbrich, Henning; Schneider, Andreas; Volk, Valery; Danisch, Simon; Gieselmann, Lutz; Ercanoglu, Meryem Seda; Messerle, Martin; von Kaisenberg, Constantin; Witte, Torsten; Klawonn, Frank; Meyer-Hermann, Michael; Klein, Florian; Stripecke, Renata

In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution

体内慢病毒基因传递HLA-DR及人源化小鼠疫苗接种促进人类T细胞及B细胞免疫重建

Suresh Kumar, Johannes Koenig, Andreas Schneider, Fredrik Wermeling, Sanjaykumar Boddul, Sebastian J Theobald, Miriam Vollmer, Doreen Kloos, Nico Lachmann, Frank Klawonn, Stefan Lienenklaus, Steven R Talbot, André Bleich, Nadine Wenzel, Constantin von Kaisenberg, James Keck, Renata Stripecke