日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

阿尔茨海默病治疗药物Lecanemab通过诱导小胶质细胞中的淀粉样蛋白清除程序来减轻Aβ病理。

Albertini Giulia, Zielonka Magdalena, Cuypers Marie-Lynn, Snellinx An, Xu Ciana, Poovathingal Suresh, Wojno Marta, Davie Kristofer, van Lieshout Veerle, Craessaerts Katleen, Wolfs Leen, Pasciuto Emanuela, Jaspers Tom, Horré Katrien, Serneels Lurgarde, Fiers Mark, Dewilde Maarten, De Strooper Bart

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health

阿尔茨海默病中的生物能量学和脂质代谢:从细胞生物学到系统健康

Maioli, Silvia; Nalvarte, Ivan; Ankarcrona, Maria; Schultzberg, Marianne; Zuloaga, Kristen L; Goikolea, Julen; Visser, Pieter Jelle; De Strooper, Bart; Winblad, Bengt; Pizzo, Paola; Williams, Pete A; Rodriguez-Rodriguez, Patricia; Naia, Luana

Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived neuron xenografts

Aβ斑块在人iPSC衍生神经元异种移植中诱导局部突触前毒性

van Vierbergen, Jacqueline Fréderique Maria; Calatayud, Carles; Balusu, Sriram; Carrano, Nicolò; Peredo, Nicolas; Vints, Katlijn; Gallego, Sandra Fernández; Horré, Katrien; De Strooper, Bart; Verstreken, Patrik

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases

一种多功能小鼠模型,可促进人类小胶质细胞移植在神经退行性疾病领域的研究

Lutgarde Serneels #, Annerieke Sierksma #, Emanuela Pasciuto #, Ivana Geric, Arya Nair, Anna Martinez-Muriana, An Snellinx, Bart De Strooper

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease

APOE同种型对移植到阿尔茨海默病小鼠模型中的人类小胶质细胞的转录组和表观基因组图谱产生不同的影响

Kitty B Murphy ,Di Hu ,Leen Wolfs ,Susan K Rohde ,Gonzalo Leguía Fauró ,Ivana Geric ,Renzo Mancuso ,Bart De Strooper ,Sarah J Marzi

The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation.

氯离子细胞内通道 1 (CLIC1) 对小胶质细胞形态动力学和神经炎症至关重要。

Rifat Ali, Bickel Tom, Kreis Patricia, Trimbuch Thorsten, Onken Julia, Ivanov Andranik, Albertini Giulia, Beule Dieter, Mazzanti Michele, Singh Harpreet, Eickholt Britta J, De Strooper Bart, Geiger Jörg R P, Madry Christian

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.

Lecanemab 优先与阿尔茨海默病早期存在的较小聚集体结合

Fertan Emre, Lam Jeff Y L, Albertini Giulia, Dewilde Maarten, Wu Yunzhao, Akingbade Oluwatomi E S, Böken Dorothea, English Elizabeth A, De Strooper Bart, Klenerman David

Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer's disease mouse model

脑渗透性补体抑制可减轻阿尔茨海默病小鼠模型中的神经退行性

Wioleta M Zelek, Ryan J Bevan, Jacqui Nimmo, Maarten Dewilde, Bart De Strooper, Bryan Paul Morgan

CTAD taskforce: genetic therapies in Alzheimer's disease

CTAD工作组:阿尔茨海默病基因疗法

Jakabek, D; Isaacs, A M; De Strooper, B; Tuszynski, M; Lane, R; Uspenskaya, O; McDade, E; Rafii, M S; Mummery, C J

Breaking Barriers: Delivering Therapeutics to the Brain in Alzheimer's Disease

突破障碍:将治疗药物输送到阿尔茨海默病患者的大脑

De Strooper, Bart; Scheltens, Philip; Salloway, Stephen