日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity.

发现并表征了具有强大髓系激活和抗肿瘤活性的首创 LIV1-TLR7/8 免疫调节偶联物

Yamazoe Sayumi, Poudel Yam, Sega Emanuela, Mukhopadhyay Anandaroop, Ramakrishnan Radha, Ukairo Okechukwu, Liu Scot, Akter Rahima, Sadanala Keerthi, Que Kathryn, Cheng Qinqin, Kotapati Srikanth, Deshpande Madhura, Cox Matthew, Chourey Shishir, Gupta Anuradha, Kempson James, Pabbisetty Kumar, Kaspady Mahammed, Bhattasali Debabrata, Yip Shiuhang, Wu Dauh-Rurng, Pookot Deepa, Li Yvonne, Kozhich Alexander, Drexler Dieter, Carl Stephen, Deyanova Ekaterina, Smith Michael, Chan Henry, West Sean, Diong S J, Chang Aram, Florin Lore, Mathur Arvind, Strop Pavel, Zapf Christoph W, Law Deborah, Wilson Nicholas, Broz Miranda, Chekler Eugene P

Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells

将TLR7激动剂靶向递送至肿瘤微环境可通过激活肿瘤驻留髓系细胞增强肿瘤免疫力

Sega, Emanuela; Kotapati, Srikanth; Poudel, Yam B; Cheng, Qinqin; Sadanala, Keerthi; Schneider, Bridget; Chekler, Eugene P; Rao, Chetana; Gangwar, Sanjeev; Sproul, Tim; Law, Deborah; Broz, Miranda; Strop, Pavel; Yamazoe, Sayumi

The Impact of Conjugation Mode and Site on Tubulysin Antibody-Drug-Conjugate Efficacy and Stability

偶联方式和位点对微管溶素抗体-药物偶联物疗效和稳定性的影响

Yamazoe, Sayumi; Cheng, Qinqin; Kotapati, Srikanth; Rangan, Vangipuram S; Sung, Mei-Chen; Deshpande, Madhura; Jashnani, Aarti; Qiang, Cong; Smith, Michael J; Pan, Chin; Dollinger, Gavin; Rajpal, Arvind; Strop, Pavel; Rao, Chetana

Design and Characterization of Prodrugged Anti-CTLA-4 Antibodies

前药化抗CTLA-4抗体的设计与表征

Yamazoe, Sayumi; Huber, Mary; Kotapati, Srikanth; Akter, Rahima; Jashnani, Aarti; Deol, Suprit; Bee, Christine; Engelhart, John; Poudel, Yam B; Krystek, Stanley; Haugner, John; Srinivasan, Mohan; Rajpal, Arvind; Zhang, Yong; Strop, Pavel; Rao, Chetana

Author Correction: Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer

作者更正:利用 CD3 双特异性抗体和抗体偶联药物 (ADC) 靶向 CLDN18.2 治疗胃癌和胰腺癌

Zhu, Guoyun; Foletti, Davide; Liu, Xiaohui; Ding, Sheng; Melton Witt, Jody; Hasa-Moreno, Adela; Rickert, Mathias; Holz, Charles; Aschenbrenner, Laura; Yang, Amy H; Kraynov, Eugenia; Evering, Winston; Obert, Leslie; Lee, Chenyu; Sai, Tao; Mistry, Tina; Lindquist, Kevin C; Van Blarcom, Thomas; Strop, Pavel; Chaparro-Riggers, Javier; Liu, Shu-Hui

The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels

MscL两亲性N端的作用揭示了机械敏感通道双层介导门控的蓝图

Bavi, Navid; Cortes, D Marien; Cox, Charles D; Rohde, Paul R; Liu, Weihong; Deitmer, Joachim W; Bavi, Omid; Strop, Pavel; Hill, Adam P; Rees, Douglas; Corry, Ben; Perozo, Eduardo; Martinac, Boris

Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1.

昆虫细胞表达的全长哺乳动物突触结合蛋白 1 的翻译后修饰和脂质结合谱

Vrljic Marija, Strop Pavel, Hill Ryan C, Hansen Kirk C, Chu Steven, Brunger Axel T

Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion

突触结合蛋白-SNARE相互作用在Ca2+触发的囊泡融合中的分子机制

Vrljic, Marija; Strop, Pavel; Ernst, James A; Sutton, R Bryan; Chu, Steven; Brunger, Axel T

Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex

基于单分子FRET技术的突触结合蛋白1-SNARE融合复合物模型

Choi, Ucheor B; Strop, Pavel; Vrljic, Marija; Chu, Steven; Brunger, Axel T; Weninger, Keith R

The longin SNARE VAMP7/TI-VAMP adopts a closed conformation

长链SNARE VAMP7/TI-VAMP呈闭合构象

Vivona, Sandro; Liu, Corey W; Strop, Pavel; Rossi, Valeria; Filippini, Francesco; Brunger, Axel T