Strovas相关文献与解析，生知库 | 链接生命科学的每一步

Pamela J McMillan, Sarah J Benbow, Rikki Uhrich, Aleen Saxton, Misa Baum, Timothy Strovas, Jeanna M Wheeler, Jeremy Baker, Nicole F Liachko, C Dirk Keene, Caitlin S Latimer, Brian C Kraemer

发表日期：2023

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Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease

病理性 tau 驱动异位核斑点支架蛋白 SRRM2 在阿尔茨海默病中的神经元细胞质中积累

期刊:Acta Neuropathologica Communications

影响因子:6.2

doi:10.1186/s40478-021-01219-1

Pamela J McMillan, Timothy J Strovas, Misa Baum, Brooke K Mitchell, Randall J Eck, Nzinga Hendricks, Jeanna M Wheeler, Caitlin S Latimer, C Dirk Keene, Brian C Kraemer

Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes

不同的 Poly(A) 核酸酶对 sut-2 依赖性 tau 蛋白病表型有不同的影响

期刊:Neurobiology of Disease

影响因子:5.1

doi:10.1016/j.nbd.2020.105148

Rebecca L Kow, Timothy J Strovas, Pamela J McMillan, Ashley M Jacobi, Mark A Behlke, Aleen D Saxton, Caitlin S Latimer, C Dirk Keene, Brian C Kraemer

信号转导

发表日期：2021

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AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery

AlphaScreen 发现用于 Tau 蛋白病靶向治疗的 MSUT2 抑制剂

期刊:SLAS Discovery

影响因子:2.7

doi:10.1177/2472555220958387

Jeremy D Baker, Rikki L Uhrich, Timothy J Strovas, Aleen D Saxton, Brian C Kraemer

多发性硬化症

发表日期：2021

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Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice

成年期泛神经元人类 tau 微管蛋白激酶 1 表达导致小鼠小脑严重神经变性

期刊:Acta Neuropathologica Communications

影响因子:6.2

doi:10.1186/s40478-020-01073-7

Pamela McMillan, Jeanna Wheeler, Rachel E Gatlin, Laura Taylor, Tim Strovas, Misa Baum, Thomas D Bird, Caitlin Latimer, C Dirk Keene, Brian C Kraemer, Nicole F Liachko

Targeting Pathological Tau by Small Molecule Inhibition of the Poly(A):MSUT2 RNA-Protein Interaction

通过小分子抑制 Poly(A):MSUT2 RNA-蛋白质相互作用来靶向病理性 Tau

期刊:ACS Chemical Neuroscience

影响因子:4.1

doi:10.1021/acschemneuro.0c00214

Jeremy D Baker, Rikki L Uhrich, Timothy J Strovas, Aleen D Saxton, Brian C Kraemer

多发性硬化症

发表日期：2020

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Synergistic toxicity between tau and amyloid drives neuronal dysfunction and neurodegeneration in transgenic C. elegans

tau 和淀粉样蛋白之间的协同毒性导致转基因秀丽隐杆线虫的神经元功能障碍和神经退行性

期刊:Human Molecular Genetics

影响因子:3.1

doi:10.1093/hmg/ddz319

Sarah J Benbow, Timothy J Strovas, Martin Darvas, Aleen Saxton, Brian C Kraemer

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

poly(A) 结合蛋白 MSUT2 的活性决定了哺乳动物大脑对病理性 tau 的易感性

期刊:Science Translational Medicine

影响因子:15.8

doi:10.1126/scitranslmed.aao6545

Jeanna M Wheeler, Pamela McMillan, Timothy J Strovas, Nicole F Liachko, Alexandre Amlie-Wolf, Rebecca L Kow, Ronald L Klein, Patricia Szot, Linda Robinson, Chris Guthrie, Aleen Saxton, Nicholas M Kanaan, Murray Raskind, Elaine Peskind, John Q Trojanowski, Virginia M Y Lee, Li-San Wang, C Dirk Keene,

信号转导

发表日期：2019

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Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

组成型 XBP-1s 介导的内质网未折叠蛋白反应激活可防止病理性 tau 蛋白的形成

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-019-12070-3

Waldherr, Sarah M; Strovas, Timothy J; Vadset, Taylor A; Liachko, Nicole F; Kraemer, Brian C

发表日期：2019

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Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy

全基因组分析揭示硫酸肝素表异构酶调节 TDP-43 蛋白病

期刊:PLoS Genetics

影响因子:

doi:10.1371/journal.pgen.1008526

Nicole F Liachko, Aleen D Saxton, Pamela J McMillan, Timothy J Strovas, C Dirk Keene, Thomas D Bird, Brian C Kraemer

发表日期：2019

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Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change

Tau-RNA 复合物抑制微管聚合并驱动疾病相关的构象变化

Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease

病理性 tau 驱动异位核斑点支架蛋白 SRRM2 在阿尔茨海默病中的神经元细胞质中积累

Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes

不同的 Poly(A) 核酸酶对 sut-2 依赖性 tau 蛋白病表型有不同的影响

AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery

AlphaScreen 发现用于 Tau 蛋白病靶向治疗的 MSUT2 抑制剂

Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice

成年期泛神经元人类 tau 微管蛋白激酶 1 表达导致小鼠小脑严重神经变性

Targeting Pathological Tau by Small Molecule Inhibition of the Poly(A):MSUT2 RNA-Protein Interaction

通过小分子抑制 Poly(A):MSUT2 RNA-蛋白质相互作用来靶向病理性 Tau

Synergistic toxicity between tau and amyloid drives neuronal dysfunction and neurodegeneration in transgenic C. elegans

tau 和淀粉样蛋白之间的协同毒性导致转基因秀丽隐杆线虫的神经元功能障碍和神经退行性

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

poly(A) 结合蛋白 MSUT2 的活性决定了哺乳动物大脑对病理性 tau 的易感性

Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

组成型 XBP-1s 介导的内质网未折叠蛋白反应激活可防止病理性 tau 蛋白的形成

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy

全基因组分析揭示硫酸肝素表异构酶调节 TDP-43 蛋白病