日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects

Acasunlimab 是一种 Fc 惰性 PD-L1×4-1BB 双特异性抗体,与 PD-1 阻断剂联合使用可通过互补的免疫调节作用增强抗肿瘤免疫力。

Michela Capello # ,Angelica Sette # ,Theo Plantinga ,Craig J Thalhauser ,Vanessa M Spires ,Kristina B Nürmberger ,Jordan M Blum ,Brandon W Higgs ,Patricia Garrido Castro ,Christina Yu ,Carol Costa Sa ,Sina Fellermeier-Kopf ,Saskia M Burm ,Kristin Strumane ,Aras Toker ,Andrea Imle ,Bruna de Andrade Pereira ,Alexander Muik ,Tahamtan Ahmadi ,Özlem Türeci ,Mark Fereshteh ,Ugur Sahin ,Maria Jure-Kunkel ,Nora Pencheva

Large Scale in vivo Acquisition, Segmentation and 3D Reconstruction of Cortical Vasculature using μ Doppler Ultrasound Imaging

利用μ多普勒超声成像技术对皮质血管进行大规模体内采集、分割和三维重建

Strumane, Anoek; Lambert, Théo; Aelterman, Jan; Babin, Danilo; Montaldo, Gabriel; Philips, Wilfried; Brunner, Clément; Urban, Alan

Multispectral indices for real-time and non-invasive tissue ischemia monitoring using snapshot cameras

利用快照相机进行实时、无创组织缺血监测的多光谱指数

De Winne, Jens; Strumane, Anoek; Babin, Danilo; Luthman, Siri; Luong, Hiep; Philips, Wilfried

DuoHexaBody-CD37(®), a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies

DuoHexaBody-CD37® 是一种新型双位点 CD37 抗体,具有增强的 Fc 介导的六聚化作用,有望成为 B 细胞恶性肿瘤的潜在治疗方法。

Oostindie, Simone C; van der Horst, Hilma J; Kil, Laurens P; Strumane, Kristin; Overdijk, Marije B; van den Brink, Edward N; van den Brakel, Jeroen H N; Rademaker, Hendrik J; van Kessel, Berris; van den Noort, Juliette; Chamuleau, Martine E D; Mutis, Tuna; Lindorfer, Margaret A; Taylor, Ronald P; Schuurman, Janine; Parren, Paul W H I; Beurskens, Frank J; Breij, Esther C W

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

CD20和CD37抗体协同作用,通过Fc介导的聚集激活补体。

Oostindie, Simone C; van der Horst, Hilma J; Lindorfer, Margaret A; Cook, Erika M; Tupitza, Jillian C; Zent, Clive S; Burack, Richard; VanDerMeid, Karl R; Strumane, Kristin; Chamuleau, Martine E D; Mutis, Tuna; de Jong, Rob N; Schuurman, Janine; Breij, Esther C W; Beurskens, Frank J; Parren, Paul W H I; Taylor, Ronald P

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

基于细胞表面抗原依赖性 IgG 六聚体的形成,增强治疗性抗体的新平台

Rob N de Jong, Frank J Beurskens, Sandra Verploegen, Kristin Strumane, Muriel D van Kampen, Marleen Voorhorst, Wendy Horstman, Patrick J Engelberts, Simone C Oostindie, Guanbo Wang, Albert J R Heck, Janine Schuurman, Paul W H I Parren

Complement is activated by IgG hexamers assembled at the cell surface

补体由细胞表面组装的IgG六聚体激活。

Diebolder, Christoph A; Beurskens, Frank J; de Jong, Rob N; Koning, Roman I; Strumane, Kristin; Lindorfer, Margaret A; Voorhorst, Marleen; Ugurlar, Deniz; Rosati, Sara; Heck, Albert J R; van de Winkel, Jan G J; Wilson, Ian A; Koster, Abraham J; Taylor, Ronald P; Saphire, Erica Ollmann; Burton, Dennis R; Schuurman, Janine; Gros, Piet; Parren, Paul W H I

HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design

HER2 单克隆抗体不会干扰受体异二聚化介导的信号传导,可诱导有效内化,是合理抗体-药物偶联物设计的重要成分

Bart E C G de Goeij, Matthias Peipp, Simone de Haij, Edward N van den Brink, Christian Kellner, Thilo Riedl, Rob de Jong, Tom Vink, Kristin Strumane, Wim K Bleeker, Paul W H I Parren

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

通过可控的Fab臂交换高效生成稳定的双特异性IgG1

Labrijn, Aran F; Meesters, Joyce I; de Goeij, Bart E C G; van den Bremer, Ewald T J; Neijssen, Joost; van Kampen, Muriel D; Strumane, Kristin; Verploegen, Sandra; Kundu, Amitava; Gramer, Michael J; van Berkel, Patrick H C; van de Winkel, Jan G J; Schuurman, Janine; Parren, Paul W H I

Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice

Tiam1缺陷会损害MMTV-c-neu小鼠的乳腺肿瘤形成,但不会影响MMTV-c-myc小鼠的乳腺肿瘤形成。

Strumane, K; Rygiel, T; van der Valk, M; Collard, J G