日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TAS2R5 screening reveals biased agonism that fails to evoke internalization and downregulation resulting in attenuated desensitization.

TAS2R5 筛选揭示了偏向性激动作用,未能引起内化和下调,导致脱敏作用减弱

Kim Donghwa, Strzelinski Hannah R, Liggett Stephen B

Agonist activation to open the Gα subunit of the GPCR-G protein precoupled complex defines functional agonist activation of TAS2R5

激动剂激活以打开 GPCR-G 蛋白预偶联复合物的 Gα 亚基,这定义了 TAS2R5 的功能性激动剂激活。

Young Yang, Moon; Duy Mac, Khuong; Strzelinski, Hannah R; Hoffman, Samantha A; Kim, Donghwa; Kim, Soo-Kyung; Su, Judith; Liggett, Stephen B; Goddard, William A 3rd

Identification and characterization of an atypical Gαs-biased β(2)AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis

鉴定和表征一种非典型Gαs偏向性β(2)肾上腺素能受体激动剂,该激动剂无法诱发气道平滑肌细胞快速耐受性

Kim, Donghwa; Tokmakova, Alina; Lujan, Lauren K; Strzelinski, Hannah R; Kim, Nicholas; Najari Beidokhti, Maliheh; Giulianotti, Marc A; Mafi, Amirhossein; Woo, Jung-A A; An, Steven S; Goddard, William A 3rd; Liggett, Stephen B