日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small Molecule Ligands of the BET-like Bromodomain, Sm BRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development

BET 样溴结构域的小分子配体 Sm BRD3 影响曼氏血吸虫的存活、产卵和发育

Matthias Schiedel, Darius J B McArdle, Gilda Padalino, Anthony K N Chan, Josephine Forde-Thomas, Michael McDonough, Helen Whiteland, Manfred Beckmann, Rosa Cookson, Karl F Hoffmann, Stuart J Conway

Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery

溴结构域因子 5 作为抗利什曼原虫药物研发的靶点

Catherine N Russell, Jennifer L Carter, Juliet M Borgia, Jacob Bush, Félix Calderón, Raquel Gabarró, Stuart J Conway, Jeremy C Mottram, Anthony J Wilkinson, Nathaniel G Jones

Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

新型缺氧激活 KDAC 抑制剂的开发和临床前测试

Anna Skwarska, Ewen D D Calder, Deborah Sneddon, Hannah Bolland, Maria L Odyniec, Ishna N Mistry, Jennifer Martin, Lisa K Folkes, Stuart J Conway, Ester M Hammond

Zap-Pano: a Photocaged Prodrug of the KDAC Inhibitor Panobinostat

Zap-Pano:KDAC 抑制剂 Panobinostat 的光笼前药

Kathrin S Troelsen, Ewen D D Calder, Anna Skwarska, Deborah Sneddon, Ester M Hammond, Stuart J Conway

Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors

含异恶唑溴结构域和额外末端结构域 (BET) 抑制剂的生物活性

Noah R Flynn, Michael D Ward, Mary A Schleiff, Corentine M C Laurin, Rohit Farmer, Stuart J Conway, Gunnar Boysen, S Joshua Swamidass, Grover P Miller

Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System

腺苷单磷酸结合稳定反硝化希瓦氏菌 Kef 钾流出系统的 KTN 结构域

Christos Pliotas, Samuel C Grayer, Silvia Ekkerman, Anthony K N Chan, Jess Healy, Phedra Marius, Wendy Bartlett, Amjad Khan, Wilian A Cortopassi, Shane A Chandler, Tim Rasmussen, Justin L P Benesch, Robert S Paton, Timothy D W Claridge, Samantha Miller, Ian R Booth, James H Naismith, Stuart J Conway

The photochemical thiol-ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef

光化学硫醇-烯反应是合成谷胱甘肽S-结合物的通用方法,靶向细菌钾外排系统 Kef

Jess Healy, Tim Rasmussen, Samantha Miller, Ian R Booth, Stuart J Conway

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

CBP/p300 溴结构域小分子配体的发现和优化

Duncan A Hay, Oleg Fedorov, Sarah Martin, Dean C Singleton, Cynthia Tallant, Christopher Wells, Sarah Picaud, Martin Philpott, Octovia P Monteiro, Catherine M Rogers, Stuart J Conway, Timothy P C Rooney, Anthony Tumber, Clarence Yapp, Panagis Filippakopoulos, Mark E Bunnage, Susanne Müller, Stefan K

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

3,5-二甲基异恶唑作为乙酰赖氨酸模拟溴结构域配体

David S Hewings, Minghua Wang, Martin Philpott, Oleg Fedorov, Sagar Uttarkar, Panagis Filippakopoulos, Sarah Picaud, Chaitanya Vuppusetty, Brian Marsden, Stefan Knapp, Stuart J Conway, Tom D Heightman

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis

促凋亡因子 Bax 和 Bak 通过控制内质网 Ca(2+) 稳态来调节 T 细胞增殖

Russell G Jones, Thi Bui, Carl White, Muniswamy Madesh, Connie M Krawczyk, Tullia Lindsten, Brian J Hawkins, Sara Kubek, Kenneth A Frauwirth, Y Lynn Wang, Stuart J Conway, H Llewelyn Roderick, Martin D Bootman, Hao Shen, J Kevin Foskett, Craig B Thompson