日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma

EZH2 与 DNA 甲基化协同作用,下调黑色素瘤中的关键肿瘤抑制因子和 IFN 基因特征

Jessamy Tiffen, Stuart J Gallagher, Fabian Filipp, Dilini Gunatilake, Abdullah Al Emran, Carleen Cullinane, Ken Dutton-Register, Lauren Aoude, Nick Hayward, Aniruddha Chatterjee, Euan J Rodger, Michael R Eccles, Peter Hersey

C57BL/6 congenic mouse NRASQ61K melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivo

C57BL/6 同类小鼠 NRASQ61K 黑色素瘤细胞系在体外和体内对 Mek 和 Akt 抑制剂的组合高度敏感

Valérie Petit, Jeremy Raymond, Christophe Alberti, Marie Pouteaux, Stuart J Gallagher, Mai Q Nguyen, Andrew E Aplin, Véronique Delmas, Lionel Larue

SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling

SIRT6 单倍体不足通过 IGF 信号传导诱导 BRAFV600E 黑色素瘤细胞对 MAPK 抑制剂产生耐药性

Thomas Strub, Flavia G Ghiraldini, Saul Carcamo, Man Li, Aleksandra Wroblewska, Rajendra Singh, Matthew S Goldberg, Dan Hasson, Zichen Wang, Stuart J Gallagher, Peter Hersey, Avi Ma'ayan, Georgina V Long, Richard A Scolyer, Brian Brown, Bin Zheng, Emily Bernstein

Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report

抗 PD-1 诱发的与皮质类固醇耐药 T 细胞相关的严重肝炎:病例报告

Helen M McGuire, Elena Shklovskaya, Jarem Edwards, Paul R Trevillian, Geoffrey W McCaughan, Patrick Bertolino, Catriona McKenzie, Ralph Gourlay, Stuart J Gallagher, Barbara Fazekas de St Groth, Peter Hersey

HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma

HDAC 抑制剂通过改变黑色素瘤亚组中的 PI3K 和生存信号来恢复 BRAF 抑制剂的敏感性

Stuart J Gallagher, Dilini Gunatilake, Kimberley A Beaumont, Danae M Sharp, Jessamy C Tiffen, Anja Heinemann, Wolfgang Weninger, Nikolas K Haass, James S Wilmott, Jason Madore, Peter M Ferguson, Helen Rizos, Peter Hersey

Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma

显著的整体 DNA 低甲基化与黑色素瘤中组成性 PD-L1 表达相关

Aniruddha Chatterjee, Euan J Rodger, Antonio Ahn, Peter A Stockwell, Matthew Parry, Jyoti Motwani, Stuart J Gallagher, Elena Shklovskaya, Jessamy Tiffen, Michael R Eccles, Peter Hersey

Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma

EZH2 的体细胞拷贝数扩增和过度活化体细胞突变与 DNA 甲基化相关,并驱动与黑色素瘤肿瘤抑制和免疫反应有关的基因的表观遗传沉默

Jessamy Tiffen, Stephen Wilson, Stuart J Gallagher, Peter Hersey, Fabian V Filipp

Inducible but not constitutive expression of PD-L1 in human melanoma cells is dependent on activation of NF-κB

人类黑色素瘤细胞中 PD-L1 的诱导表达(而非组成性表达)依赖于 NF-κB 的激活

Kavitha Gowrishankar, Dilini Gunatilake, Stuart J Gallagher, Jessamy Tiffen, Helen Rizos, Peter Hersey

Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes

靶向 EZH2 激活突变可通过解除肿瘤抑制基因的抑制而有效抑制人类黑色素瘤细胞的生长

Jessamy C Tiffen, Dilini Gunatilake, Stuart J Gallagher, Kavitha Gowrishankar, Anja Heinemann, Carleen Cullinane, Ken Dutton-Regester, Gulietta M Pupo, Dario Strbenac, Jean Y Yang, Jason Madore, Graham J Mann, Nicholas K Hayward, Grant A McArthur, Fabian V Filipp, Peter Hersey

Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling

BET 和 HDAC 抑制剂联合使用可协同诱导黑色素瘤细胞凋亡并抑制 AKT 和 YAP 信号传导

Anja Heinemann, Carleen Cullinane, Ricardo De Paoli-Iseppi, James S Wilmott, Dilini Gunatilake, Jason Madore, Dario Strbenac, Jean Y Yang, Kavitha Gowrishankar, Jessamy C Tiffen, Rab K Prinjha, Nicholas Smithers, Grant A McArthur, Peter Hersey, Stuart J Gallagher