SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling
SIRT6 单倍体不足通过 IGF 信号传导诱导 BRAFV600E 黑色素瘤细胞对 MAPK 抑制剂产生耐药性
期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-018-05966-z
Thomas Strub, Flavia G Ghiraldini, Saul Carcamo, Man Li, Aleksandra Wroblewska, Rajendra Singh, Matthew S Goldberg, Dan Hasson, Zichen Wang, Stuart J Gallagher, Peter Hersey, Avi Ma'ayan, Georgina V Long, Richard A Scolyer, Brian Brown, Bin Zheng, Emily Bernstein
信号转导
肿瘤
黑色素瘤
肿瘤细胞
WB
MAPK/ERK
HAT1