The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models
PARP 抑制剂 AZD2461 为临床前模型中 PARP3 抑制对化疗的合成致死率和耐受性的作用提供了见解
期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-15-3240
Lenka Oplustil O'Connor, Stuart L Rulten, Aaron N Cranston, Rajesh Odedra, Henry Brown, Janneke E Jaspers, Louise Jones, Charlotte Knights, Bastiaan Evers, Attilla Ting, Robert H Bradbury, Marina Pajic, Sven Rottenberg, Jos Jonkers, David Rudge, Niall M B Martin, Keith W Caldecott, Alan Lau, Mark J