日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia

XRCC1 突变与 PARP1 过度激活和小脑共济失调有关

Nicolas C Hoch, Hana Hanzlikova, Stuart L Rulten, Martine Tétreault, Emilia Komulainen, Limei Ju, Peter Hornyak, Zhihong Zeng, William Gittens, Stephanie A Rey, Kevin Staras, Grazia M S Mancini, Peter J McKinnon, Zhao-Qi Wang, Justin D Wagner; Care4Rare Canada Consortium; Grace Yoon, Keith W Caldeco

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)

PARP3 是缺口核小体和单核糖基化组蛋白 H2B(Glu2)的传感器

Gabrielle J Grundy, Luis M Polo, Zhihong Zeng, Stuart L Rulten, Nicolas C Hoch, Pathompong Paomephan, Yingqi Xu, Steve M Sweet, Alan W Thorne, Antony W Oliver, Steve J Matthews, Laurence H Pearl, Keith W Caldecott

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

Ku 结合基序是募集和刺激非同源末端连接蛋白的保守模块

Gabrielle J Grundy, Stuart L Rulten, Raquel Arribas-Bosacoma, Kathryn Davidson, Zuzanna Kozik, Antony W Oliver, Laurence H Pearl, Keith W Caldecott

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

PARP 抑制剂 AZD2461 为临床前模型中 PARP3 抑制对化疗的合成致死率和耐受性的作用提供了见解

Lenka Oplustil O'Connor, Stuart L Rulten, Aaron N Cranston, Rajesh Odedra, Henry Brown, Janneke E Jaspers, Louise Jones, Charlotte Knights, Bastiaan Evers, Attilla Ting, Robert H Bradbury, Marina Pajic, Sven Rottenberg, Jos Jonkers, David Rudge, Niall M B Martin, Keith W Caldecott, Alan Lau, Mark J

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

XRCC1 磷酸结合口袋可结合聚(ADP-核糖),是 XRCC1 功能所必需的

Claire Breslin, Peter Hornyak, Andrew Ridley, Stuart L Rulten, Hana Hanzlikova, Antony W Oliver, Keith W Caldecott

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage

PARP-1 依赖性募集肌萎缩侧索硬化症相关蛋白 FUS/TLS 至氧化性 DNA 损伤位点

Stuart L Rulten, Amy Rotheray, Ryan L Green, Gabrielle J Grundy, Duncan A Q Moore, Fernando Gómez-Herreros, Majid Hafezparast, Keith W Caldecott

APLF promotes the assembly and activity of non-homologous end joining protein complexes

APLF 促进非同源末端连接蛋白复合物的组装和活性

Gabrielle J Grundy, Stuart L Rulten, Zhihong Zeng, Raquel Arribas-Bosacoma, Natasha Iles, Katie Manley, Antony Oliver, Keith W Caldecott