日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization

从实验室到临床:利用种子配对不稳定提高 GalNAc-siRNA 结合物的临床安全性

Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Wo

RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models

针对血管紧张素原的 RNA 干扰疗法可改善啮齿动物模型中的先兆子痫表型

Nadine Haase, Donald J Foster, Mark W Cunningham, Julia Bercher, Tuyen Nguyen, Svetlana Shulga-Morskaya, Stuart Milstein, Sarfraz Shaikh, Jeff Rollins, Michaela Golic, Florian Herse, Kristin Kräker, Ivo Bendix, Meray Serdar, Hanna Napieczynska, Arnd Heuser, Alexandra Gellhaus, Kristin Thiele, Gerd W

Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers

通过工程化人类微肝输送核酸来促进药物研发

Liliana Mancio-Silva, Heather E Fleming, Alex B Miller, Stuart Milstein, Abigail Liebow, Patrick Haslett, Laura Sepp-Lorenzino, Sangeeta N Bhatia

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

先进的 siRNA 设计进一步改善了 GalNAc-siRNA 结合物的体内性能

Donald J Foster, Christopher R Brown, Sarfraz Shaikh, Casey Trapp, Mark K Schlegel, Kun Qian, Alfica Sehgal, Kallanthottathil G Rajeev, Vasant Jadhav, Muthiah Manoharan, Satya Kuchimanchi, Martin A Maier, Stuart Milstein

Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans

CPEB 家族成员对秀丽隐杆线虫生殖系细胞凋亡和生殖细胞分化的差异调节

Kapil Dev Singh, Xue Zheng, Stuart Milstein, Martin Keller, Bernd Roschitzki, Jonas Grossmann, Michael O Hengartner

Methods to Identify and Characterize siRNAs Targeting Serpin A1 In Vitro and In Vivo Using RNA Interference

使用 RNA 干扰技术在体内和体外识别和鉴定靶向 Serpin A1 的 siRNA 的方法

Stuart Milstein, Kun Qian, Linying Zhang, Alfica Sehgal

Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis

RNAi 作为转甲状腺素蛋白介导的淀粉样变性治疗的临床前评估

James S Butler, Amy Chan, Susete Costelha, Shannon Fishman, Jennifer L S Willoughby, Todd D Borland, Stuart Milstein, Donald J Foster, Paula Gonçalves, Qingmin Chen, June Qin, Brian R Bettencourt, Dinah W Sah, Rene Alvarez, Kallanthottathil G Rajeev, Muthiah Manoharan, Kevin Fitzgerald, Rachel E Mey

Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification

使用循环 RNA 定量技术进行皮下 ALAS1 RNAi 治疗肝卟啉症的临床前开发

Amy Chan, Abigail Liebow, Makiko Yasuda, Lin Gan, Tim Racie, Martin Maier, Satya Kuchimanchi, Don Foster, Stuart Milstein, Klaus Charisse, Alfica Sehgal, Muthiah Manoharan, Rachel Meyers, Kevin Fitzgerald, Amy Simon, Robert J Desnick, William Querbes

Evaluation of exogenous siRNA addition as a metabolic engineering tool for modifying biopharmaceuticals

评估添加外源 siRNA 作为修饰生物制药的代谢工程工具

Seshu Tummala, Michael Titus, Lee Wilson, Chunhua Wang, Carlo Ciatto, Greg Thill, Donald Foster, Chen Li, Zoltan Szabo, Andras Guttman, Brian Bettencourt, Muthuswamy Jayaraman, Jack Deroot, David Kocisko, Stuart Pollard, Klaus Charisse, Satya Kuchimanchi, Greg Hinkle, Stuart Milstein, Rachel Meyers,

Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice

内质网应激和 mTORC1 的激活可抑制肥胖小鼠肝脏分选蛋白-1 的水平

Ding Ai, Juan M Baez, Hongfeng Jiang, Donna M Conlon, Antonio Hernandez-Ono, Maria Frank-Kamenetsky, Stuart Milstein, Kevin Fitzgerald, Andrew J Murphy, Connie W Woo, Alanna Strong, Henry N Ginsberg, Ira Tabas, Daniel J Rader, Alan R Tall