日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MAP3K8 is a potential therapeutic target in airway epithelial inflammation

MAP3K8 是气道上皮炎症的潜在治疗靶点

Chih-Yung Chiu, Saffron A G Willis-Owen, Kenny C C Wong, Stuart N Farrow, William O C Cookson, Miriam F Moffatt, Youming Zhang

Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

在斑马鱼表型筛选中鉴定出苯并吡喃酮是具有抗炎活性的化合物的共同结构特征

Anne L Robertson, Nikolay V Ogryzko, Katherine M Henry, Catherine A Loynes, Matthew J Foulkes, Marco M Meloni, Xingang Wang, Christopher Ford, Malcolm Jackson, Philip W Ingham, Heather L Wilson, Stuart N Farrow, Roberto Solari, Roderick J Flower, Simon Jones, Moira K B Whyte, Stephen A Renshaw2

Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy

糖皮质激素受体调节精确的染色体分离并与恶性肿瘤有关

Laura C Matthews, Andrew A Berry, David J Morgan, Toryn M Poolman, Kerstin Bauer, Frederike Kramer, David G Spiller, Rachel V Richardson, Karen E Chapman, Stuart N Farrow, Michael R Norman, Andrew J K Williamson, Anthony D Whetton, Stephen S Taylor, Jan P Tuckermann, Michael R H White, David W Ray

A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism

斑马鱼化合物筛选揭示了调节中性粒细胞逆向迁移作为一种抗炎机制

Anne L Robertson, Geoffrey R Holmes, Aleksandra N Bojarczuk, Joseph Burgon, Catherine A Loynes, Myriam Chimen, Amy K Sawtell, Bashar Hamza, Joseph Willson, Sarah R Walmsley, Sean R Anderson, Mark C Coles, Stuart N Farrow, Roberto Solari, Simon Jones, Lynne R Prince, Daniel Irimia, G Ed Rainger, Visa

The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer

甲基转移酶 WBSCR22/Merm1 可增强糖皮质激素受体功能,并在肺部炎症和癌症中受到调节

Maryam Jangani, Toryn M Poolman, Laura Matthews, Nan Yang, Stuart N Farrow, Andrew Berry, Neil Hanley, Andrew J K Williamson, Anthony D Whetton, Rachelle Donn, David W Ray

Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution

血清和糖皮质激素调节激酶 1 在炎症消退期间调节中性粒细胞清除

Joseph Burgon, Anne L Robertson, Pranvera Sadiku, Xingang Wang, Edward Hooper-Greenhill, Lynne R Prince, Paul Walker, Emily E Hoggett, Jonathan R Ward, Stuart N Farrow, William J Zuercher, Philip Jeffrey, Caroline O Savage, Philip W Ingham, Adam F Hurlstone, Moira K B Whyte, Stephen A Renshaw

Pin1 promotes GR transactivation by enhancing recruitment to target genes

Pin1通过增强对靶基因的募集来促进GR转录激活

Toryn M Poolman, Stuart N Farrow, Laura Matthews, Andrew S Loudon, David W Ray

A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function

配体特异性动力学开关调节糖皮质激素受体的运输和功能

Peter J Trebble, James M Woolven, Ken A Saunders, Karen D Simpson, Stuart N Farrow, Laura C Matthews, David W Ray

Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504)

地塞米松和 p38 丝裂原活化蛋白激酶抑制剂 N-氰基-N'-(2-{[8-(2,6-二氟苯基)-4-(4-氟-2-甲基苯基)-7-氧代-7,8-二氢吡啶并[2,3-d]嘧啶-2-基]氨基}乙基)胍 (SB706504) 抑制脂多糖刺激的慢性阻塞性肺病巨噬细胞炎症基因表达

Lauren M Kent, Lucy J C Smyth, Jonathan Plumb, Chris L Clayton, Steve M Fox, David W Ray, Stuart N Farrow, Dave Singh

Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease

亲和力增强的糖皮质激素糠酸氟替卡松在体外和体内呼吸道炎症疾病模型中的药理特性

Mark Salter, Keith Biggadike, Joyce L Matthews, Michael R West, Michael V Haase, Stuart N Farrow, Iain J Uings, David W Gray