日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Second-Generation Cap Analogue Prodrugs for Targeting Aberrant Eukaryotic Translation Initiation Factor 4E Activity in Cancer

用于靶向治疗癌症中异常真核翻译起始因子4E活性的第二代帽类似物前药

Cárdenas, Emilio L; O'Rourke, Rachel L; Menon, Arya; Vega-Hernández, Gabriela; Meagher, Jennifer; Stuckey, Jeanne; Garner, Amanda L

Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression

SD-436 的发现:一种强效、高选择性和高效的 STAT3 PROTAC 降解剂,能够实现完全且持久的肿瘤消退

Xu, Renqi; Zhou, Haibin; Bai, Longchuan; McEachern, Donna; Wu, Dimin; Acharyya, Ranjan Kumar; Wang, Mi; Tošović, Jelena; Yang, Chao-Yie; Chinnaswamy, Krishnapriya; Meagher, Jennifer L; Stuckey, Jeanne A; Liu, Cai; Wang, Meilin; Wen, Bo; Sun, Duxin; Wang, Shaomeng

Second-Generation Cap Analogue Prodrugs for Targeting Aberrant Eukaryotic Translation Initiation Factor 4E (eIF4E) Activity in Drug-Resistant Melanoma

用于靶向耐药性黑色素瘤中异常真核翻译起始因子4E (eIF4E) 活性的第二代帽类似物前药

Cárdenas, Emilio L; O'Rourke, Rachel L; Menon, Arya; Vega-Hernández, Gabriela; Meagher, Jennifer; Stuckey, Jeanne; Garner, Amanda L

Comprehensive Analyses of the Effects of the Small-Molecule Inhibitor of the UHM Domain in the Splicing Factor U2AF1 in Leukemia Cells

对白血病细胞中剪接因子U2AF1的UHM结构域小分子抑制剂作用的综合分析

Yuan, Xinrui; Sabzvar, Mona Kazemi; Patil, Amol D; Chinnaswamy, Krishnapriya; Howie, Kathryn L; Andhavaram, Ramaraju; Wang, Borwyn; Siegler, Maxime A; Dumaz, Arda; Stuckey, Jeanne A; Corey, Seth J; Maciejewski, Jaroslaw P; Visconte, Valeria; Yang, Chao-Yie

Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease

1-(呋喃-2-基甲基)吡咯烷类刺激-2 (ST2) 抑制剂治疗移植物抗宿主病的构效关系

Yuan, Xinrui; Jiang, Hua; Fu, Denggang; Robida, Aaron; Rajanayake, Krishani; Yuan, Hebao; Wen, Bo; Sun, Duxin; Watch, Brennan T; Chinnaswamy, Krishnapriya; Stuckey, Jeanne A; Paczesny, Sophie; Rech, Jason C; Yang, Chao-Yie

Open Reading Frame 1 Protein of the Human Long Interspersed Nuclear Element 1 Retrotransposon Binds Multiple Equivalents of Lead

人类长散在核元件1逆转录转座子的开放阅读框1蛋白结合多个铅当量

Pinter, Tyler B J; Ruckthong, Leela; Stuckey, Jeanne A; Deb, Aniruddha; Penner-Hahn, James E; Pecoraro, Vincent L

Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.

发现 M-808 是一种高效的共价小分子抑制剂,可抑制 Menin-MLL 相互作用,并具有很强的体内抗肿瘤活性

Xu Shilin, Aguilar Angelo, Huang Liyue, Xu Tianfeng, Zheng Ke, McEachern Donna, Przybranowski Sally, Foster Caroline, Zawacki Kaitlin, Liu Zhaomin, Chinnaswamy Krishnapriya, Stuckey Jeanne, Wang Shaomeng

Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase

发现MLL甲基转移酶的强效小分子抑制剂

Chern, Ting-Rong; Liu, Liu; Petrunak, Elyse; Stuckey, Jeanne A; Wang, Mi; Bernard, Denzil; Zhou, Haibin; Lee, Shirley; Dou, Yali; Wang, Shaomeng

Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences

锌指抗病毒蛋白与RNA复合物的结构揭示了其选择性靶向富含CG序列的病毒序列的机制。

Meagher, Jennifer L; Takata, Matthew; Gonçalves-Carneiro, Daniel; Keane, Sarah C; Rebendenne, Antoine; Ong, Heley; Orr, Victoria K; MacDonald, Margaret R; Stuckey, Jeanne A; Bieniasz, Paul D; Smith, Janet L

Changing the Apoptosis Pathway through Evolutionary Protein Design

通过进化蛋白质设计改变细胞凋亡通路

Shultis, David; Mitra, Pralay; Huang, Xiaoqiang; Johnson, Jarrett; Khattak, Naureen Aslam; Gray, Felicia; Piper, Clint; Czajka, Jeff; Hansen, Logan; Wan, Bingbing; Chinnaswamy, Krishnapriya; Liu, Liu; Wang, Mi; Pan, Jingxi; Stuckey, Jeanne; Cierpicki, Tomasz; Borchers, Christoph H; Wang, Shaomeng; Lei, Ming; Zhang, Yang