日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity

O-GlcNAc修饰GPCR肽激动剂可提高其稳定性和体内活性。

Levine, Paul M; Balana, Aaron T; Sturchler, Emmanuel; Koole, Cassandra; Noda, Hiroshi; Zarzycka, Barbara; Daley, Eileen J; Truong, Tin T; Katritch, Vsevolod; Gardella, Thomas J; Wootten, Denise; Sexton, Patrick M; McDonald, Patricia; Pratt, Matthew R

Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119

鉴定新型、结构多样的GPR119小分子调节剂

Nieto, Ainhoa; Fernández-Vega, Virneliz; Spicer, Timothy P; Sturchler, Emmanuel; Adhikari, Pramisha; Kennedy, Nicole; Mandat, Sean; Chase, Peter; Scampavia, Louis; Bannister, Thomas; Hodder, Peter; McDonald, Patricia H

Structural mechanism of ligand activation in human calcium-sensing receptor

人类钙敏感受体配体激活的结构机制

Geng, Yong; Mosyak, Lidia; Kurinov, Igor; Zuo, Hao; Sturchler, Emmanuel; Cheng, Tat Cheung; Subramanyam, Prakash; Brown, Alice P; Brennan, Sarah C; Mun, Hee-Chang; Bush, Martin; Chen, Yan; Nguyen, Trang X; Cao, Baohua; Chang, Donald D; Quick, Matthias; Conigrave, Arthur D; Colecraft, Henry M; McDonald, Patricia; Fan, Qing R

Structure-activity relationship study of angiotensin II analogs in terms of β-arrestin-dependent signaling to aldosterone production

血管紧张素II类似物通过β-arrestin依赖性信号通路调控醛固酮生成的构效关系研究

Valero, Thairy Reyes; Sturchler, Emmanuel; Jafferjee, Malika; Rengo, Giuseppe; Magafa, Vassiliki; Cordopatis, Paul; McDonald, Patricia; Koch, Walter J; Lymperopoulos, Anastasios

Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects

自分泌选择具有强效抗糖尿病作用的GLP-1R G蛋白偏向性激动剂

Zhang, Hongkai; Sturchler, Emmanuel; Zhu, Jiang; Nieto, Ainhoa; Cistrone, Philip A; Xie, Jia; He, LinLing; Yea, Kyungmoo; Jones, Teresa; Turn, Rachel; Di Stefano, Peter S; Griffin, Patrick R; Dawson, Philip E; McDonald, Patricia H; Lerner, Richard A

Site-specific blockade of RAGE-Vd prevents amyloid-beta oligomer neurotoxicity.

针对 RAGE-Vd 的位点特异性阻断可预防淀粉样蛋白β寡聚体的神经毒性

Sturchler Emmanuel, Galichet Arnaud, Weibel Mirjam, Leclerc Estelle, Heizmann Claus W