Discovery and optimization of pyrrolopyrimidines as highly potent, selective and brain-penetrant LRRK2 inhibitors
发现和优化吡咯并嘧啶类化合物作为高效、选择性强且能穿透血脑屏障的LRRK2抑制剂
期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md00856e
Axten, Jeffrey M; Ding, Xiao; Stasi, Luigi Piero; Zhao, Baowei; Sang, Yingxia; Ho, Ming-Hsun; Wang, Lizhen; Zhang, Minhua; Guo, Xianjun; Tan, Chengfang; Feng, Xu; Edge, Colin; Valko, Klara; Li, Yi; Dong, Kelly; Guan, Xiaoming; Zinn, Nico; David Tattersall, F; Ren, Feng; Su, Dai-Shi; Reith, Alastair D