日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy

急性髓系白血病线粒体水解ATP以支持氧化代谢并抵抗化疗

James T Hagen,McLane M Montgomery,Raphael T Aruleba,Brett R Chrest,Polina Krassovskaia,Thomas D Green,Emely A Pacheco,Miki Kassai,Tonya N Zeczycki,Cameron A Schmidt,Debajit Bhowmick,Su-Fern Tan,David J Feith,Charles E Chalfant,Thomas P Loughran Jr,Darla Liles,Mark D Minden,Aaron D Schimmer,Md Salman Shakil,Matthew J McBride,Myles C Cabot,Joseph M McClung,Kelsey H Fisher-Wellman

A fluorogenic substrate for the detection of lipid amidases in intact cells

用于检测完整细胞中的脂质酰胺酶的荧光底物

Mireia Casasampere, Johnson Ung, Alejandro Iñáñez, Carine Dufau, Kazuhito Tsuboi, Josefina Casas, Su-Fern Tan, David J Feith, Nathalie Andrieu-Abadie, Bruno Segui, Thomas P Loughran Jr, José Luis Abad, Gemma Fabrias

Mitochondria inside acute myeloid leukemia cells hydrolyze ATP to resist chemotherapy

急性髓系白血病细胞内的线粒体水解ATP以抵抗化疗

James T Hagen, Mclane M Montgomery, Raphael T Aruleba, Brett R Chrest, Thomas D Green, Miki Kassai, Tonya N Zeczycki, Cameron A Schmidt, Debajit Bhowmick, Su-Fern Tan, David J Feith, Charles E Chalfant, Thomas P Loughran Jr, Darla Liles, Mark D Minden, Aaron D Schimmer, Myles C Cabot, Joseph M Mclun

Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types

泛组织线粒体表型分析表明,不同癌症类型的 OXPHOS 表达和功能均较低

Ilya N Boykov #, McLane M Montgomery #, James T Hagen, Raphael T Aruleba, Kelsey L McLaughlin, Hannah S Coalson, Margaret A Nelson, Andrea S Pereyra, Jessica M Ellis, Tonya N Zeczycki, Nasreen A Vohra, Su-Fern Tan, Myles C Cabot, Kelsey H Fisher-Wellman

Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

酸性神经酰胺酶抑制剂 LCL-805 拮抗 Akt 信号并促进急性髓系白血病中的铁依赖性细胞死亡

Johnson Ung, Su-Fern Tan, Todd E Fox, Jeremy J P Shaw, Maansi Taori, Bethany J Horton, Upendarrao Golla, Arati Sharma, Zdzislaw M Szulc, Hong-Gang Wang, Charles E Chalfant, Myles C Cabot, David F Claxton, Thomas P Loughran Jr, David J Feith

Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia

鞘脂组成和线粒体生物能量学的改变代表了与白血病多药耐药性相关的协同治疗脆弱性

Kelsey H Fisher-Wellman, James T Hagen, Miki Kassai, Li-Pin Kao, Margaret A M Nelson, Kelsey L McLaughlin, Hannah S Coalson, Todd E Fox, Su-Fern Tan, David J Feith, Mark Kester, Thomas P Loughran Jr, David F Claxton, Myles C Cabot

Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia

神经酰胺纳米脂质体增强维奈克拉和阿糖胞苷在急性髓系白血病模型中的疗效

Andrei V Khokhlatchev, Arati Sharma, Tye G Deering, Jeremy J P Shaw, Pedro Costa-Pinheiro, Upendarrao Golla, Charyguly Annageldiyev, Myles C Cabot, Mark R Conaway, Su-Fern Tan, Johnson Ung, David J Feith, Thomas P Loughran Jr, David F Claxton, Todd E Fox, Mark Kester

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

新型靛蓝类似物 KS99 靶向急性髓系白血病的干细胞标志物

Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su-Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J Feith, Thomas P Loughran Jr, Shantu Amin, David Claxton, Arati Sharma

Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1

鞘氨醇激酶-2 在大颗粒淋巴细胞白血病中过度表达,并通过 Mcl-1 促进存活

Francis R LeBlanc, Jennifer M Pearson, Su-Fern Tan, HeeJin Cheon, Jeffrey C Xing, Wendy Dunton, David J Feith, Thomas P Loughran Jr

Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia

神经酰胺类似物 SACLAC 通过调节鞘脂水平和 MCL-1 剪接诱导急性髓系白血病细胞凋亡

Jennifer M Pearson ,Su-Fern Tan ,Arati Sharma ,Charyguly Annageldiyev ,Todd E Fox ,Jose Luis Abad ,Gemma Fabrias ,Dhimant Desai ,Shantu Amin ,Hong-Gang Wang ,Myles C Cabot ,David F Claxton ,Mark Kester ,David J Feith ,Thomas P Loughran