日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model

PAI-1 的强效抑制剂 MDI-2517 可减轻临床前系统性硬化症模型中的疾病严重程度。

期刊:JCI Insight
影响因子:6.1
doi:10.1172/jci.insight.195005
Su, Enming J; Tsou, Pei-Suen; Warnock, Mark; Subbotina, Natalya; Mann, Kris; Vichaikul, Sirapa; Rosek, Alyssa; Leung, Lisa; Xing, Xianying; Xing, Enze; Plazyo, Olesya; Bogle, Rachael; Tsoi, Lam C; Emal, Cory D; Khanna, Dinesh; Varga, John; Sisson, Thomas H; Gudjonsson, Johann E; Lawrence, Daniel A
免疫/内分泌
系统性硬化症
发表日期：2026
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PAI-1 interaction with sortilin-related receptor 1 is required for lung fibrosis.

PAI-1 与 sortilin 相关受体 1 的相互作用是肺纤维化所必需的

期刊:JCI Insight
影响因子:6.1
doi:10.1172/jci.insight.186131
Sisson Thomas H, Osterholzer John J, Leung Lisa, Basrur Venkatesha, Nesvizhskii Alexey, Subbotina Natalya, Warnock Mark, Torrente Daniel, Virk Ammara Q, Gutor Sergey S, Horowitz Jeffrey C, Migliorini Mary, Strickland Dudley K, Kim Kevin K, Huang Steven K, Lawrence Daniel A
信号转导
发表日期：2025
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Degradation of oxidized phospholipids by lysosomal phospholipase A2 regulates pulmonary fibrosis.

溶酶体磷脂酶 A2 对氧化磷脂的降解调节肺纤维化

期刊:American Journal of Physiology-Lung Cellular and Molecular Physiology
影响因子:3.5
doi:10.1152/ajplung.00038.2025
Kwak Doyun, Ling Song, Subbotina Natalya, Shayman James A, Sisson Tomas H, Kim Kevin K
免疫/内分泌
发表日期：2025
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Targeting Plasminogen Activator Inhibitor-1 with a Novel Small Molecule Inhibitor Attenuates Lung Fibrosis.

利用新型小分子抑制剂靶向纤溶酶原激活物抑制剂-1可减轻肺纤维化

期刊:
影响因子:
doi:10.21203/rs.3.rs-6951289/v1
Sisson Thomas H, Fortier Sean, Tsoi Lam C, Alonzo Roxann, Subbotina Natalya, Warnock Mark, Mann Kris, Gutor Sergey S, Hartman J Craig, Gudjonsson Johann E, Su Enming J, Emal Cory D, Lawrence Daniel A
信号转导
发表日期：2025
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Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis

尿激酶型纤溶酶原激活剂过表达可逆转已形成的肺纤维化

期刊:Thrombosis and Haemostasis
影响因子:4.3
doi:10.1055/s-0039-1697953
Horowitz, Jeffrey C; Tschumperlin, Daniel J; Kim, Kevin K; Osterholzer, John J; Subbotina, Natalya; Ajayi, Iyabode O; Teitz-Tennenbaum, Seagal; Virk, Ammara; Dotson, Megan; Liu, Fei; Sicard, Delphine; Jia, Shijing; Sisson, Thomas H
信号转导
发表日期：2019
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Phosphodiesterase 4 inhibition reduces lung fibrosis following targeted type II alveolar epithelial cell injury

磷酸二酯酶 4 抑制剂可减轻靶向 II 型肺泡上皮细胞损伤后的肺纤维化。

期刊:Physiological Reports
影响因子:1.9
doi:10.14814/phy2.13753
Sisson, Thomas H; Christensen, Paul J; Muraki, Yo; Dils, Anthony J; Chibucos, Lauren; Subbotina, Natalya; Tohyama, Kimio; Horowitz, Jeffrey C; Matsuo, Takanori; Bailie, Marc; Nikam, Sham; Hazama, Masatoshi
上皮细胞
细胞生物学
发表日期：2018
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Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis

靶向凋亡抑制蛋白可预防博来霉素诱导的肺纤维化

期刊:American Journal of Respiratory Cell and Molecular Biology
影响因子:5.3
doi:10.1165/rcmb.2015-0148OC
Ashley, Shanna L; Sisson, Thomas H; Wheaton, Amanda K; Kim, Kevin K; Wilke, Carol A; Ajayi, Iyabode O; Subbotina, Natalya; Wang, Shaomeng; Duckett, Colin S; Moore, Bethany B; Horowitz, Jeffrey C
凋亡
表观遗传
Apoptosis
发表日期：2016
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Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis

抑制心肌相关转录因子/血清反应因子信号传导可减少肺纤维化并促进间充质细胞凋亡

期刊:American Journal of Pathology
影响因子:3.6
doi:10.1016/j.ajpath.2014.12.005
Sisson, Thomas H; Ajayi, Iyabode O; Subbotina, Natalya; Dodi, Amos E; Rodansky, Eva S; Chibucos, Lauren N; Kim, Kevin K; Keshamouni, Venkateshwar G; White, Eric S; Zhou, Yong; Higgins, Peter D R; Larsen, Scott D; Neubig, Richard R; Horowitz, Jeffrey C
信号转导
细胞生物学
凋亡
表观遗传
发表日期：2015
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PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury

PAI-1促进渗出性巨噬细胞的聚集，并加重II型肺泡上皮细胞损伤后的肺纤维化。

期刊:Journal of Pathology
影响因子:5.2
doi:10.1002/path.3992
Osterholzer, John J; Christensen, Paul J; Lama, Vibha; Horowitz, Jeffrey C; Hattori, Noboru; Subbotina, Natalya; Cunningham, Andrew; Lin, Yujing; Murdock, Benjamin J; Morey, Roger E; Olszewski, Michal A; Lawrence, Daniel A; Simon, Richard H; Sisson, Thomas H
上皮细胞
免疫/内分泌
巨噬细胞
细胞生物学
巨噬细胞
发表日期：2012
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Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis

靶向损伤II型肺泡上皮细胞可诱发肺纤维化

期刊:American Journal of Respiratory and Critical Care Medicine
影响因子:19.4
doi:10.1164/rccm.200810-1615OC
Sisson, Thomas H; Mendez, Michael; Choi, Karen; Subbotina, Natalya; Courey, Anthony; Cunningham, Andrew; Dave, Aditi; Engelhardt, John F; Liu, Xiaoming; White, Eric S; Thannickal, Victor J; Moore, Bethany B; Christensen, Paul J; Simon, Richard H
上皮细胞
细胞生物学
发表日期：2010
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