日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons

基于CRISPR技术的小鼠海马神经元培养中内源性α-突触核蛋白操控与可视化实验方案

Leonardo A Parra-Rivas,Rohan Sharma,Trinity E Rust,Hannah O Bazick,Jared Carlson-Stevermer,Mark J Zylka,Yuki Ogawa,Subhojit Roy

Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function

α-突触核蛋白丝氨酸129位点的磷酸化是生理性蛋白质-蛋白质相互作用和突触功能的活性依赖性触发因素。

Leonardo A Parra-Rivas,Kayalvizhi Madhivanan,Brent D Aulston,Lina Wang,Dube Dheeraj Prakashchand,Nicholas P Boyer,Veronica M Saia-Cereda,Kristen Branes-Guerrero,Donald P Pizzo,Pritha Bagchi,V S Sundar,Yong Tang,Utpal Das,David A Scott,Padmini Rangamani,Yuki Ogawa,Subhojit Roy

Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration

神经元 ESCRT-0 功能减弱加剧 AMPA 受体错乱并加速朊病毒诱导的神经退行性

Jessica A Lawrence, Patricia Aguilar-Calvo, Daniel Ojeda-Juárez, Helen Khuu, Katrin Soldau, Donald P Pizzo, Jin Wang, Adela Malik, Timothy F Shay, Erin E Sullivan, Brent Aulston, Seung Min Song, Julia A Callender, Henry Sanchez, Michael D Geschwind, Subhojit Roy, Robert A Rissman, JoAnn Trejo, Nobuy

The NIH Somatic Cell Genome Editing program

美国国立卫生研究院体细胞基因组编辑计划

Saha, Krishanu; Sontheimer, Erik J; Brooks, P J; Dwinell, Melinda R; Gersbach, Charles A; Liu, David R; Murray, Stephen A; Tsai, Shengdar Q; Wilson, Ross C; Anderson, Daniel G; Asokan, Aravind; Banfield, Jillian F; Bankiewicz, Krystof S; Bao, Gang; Bulte, Jeff W M; Bursac, Nenad; Campbell, Jarryd M; Carlson, Daniel F; Chaikof, Elliot L; Chen, Zheng-Yi; Cheng, R Holland; Clark, Karl J; Curiel, David T; Dahlman, James E; Deverman, Benjamin E; Dickinson, Mary E; Doudna, Jennifer A; Ekker, Stephen C; Emborg, Marina E; Feng, Guoping; Freedman, Benjamin S; Gamm, David M; Gao, Guangping; Ghiran, Ionita C; Glazer, Peter M; Gong, Shaoqin; Heaney, Jason D; Hennebold, Jon D; Hinson, John T; Khvorova, Anastasia; Kiani, Samira; Lagor, William R; Lam, Kit S; Leong, Kam W; Levine, Jon E; Lewis, Jennifer A; Lutz, Cathleen M; Ly, Danith H; Maragh, Samantha; McCray, Paul B Jr; McDevitt, Todd C; Mirochnitchenko, Oleg; Morizane, Ryuji; Murthy, Niren; Prather, Randall S; Ronald, John A; Roy, Subhojit; Roy, Sushmita; Sabbisetti, Venkata; Saltzman, W Mark; Santangelo, Philip J; Segal, David J; Shimoyama, Mary; Skala, Melissa C; Tarantal, Alice F; Tilton, John C; Truskey, George A; Vandsburger, Moriel; Watts, Jonathan K; Wells, Kevin D; Wolfe, Scot A; Xu, Qiaobing; Xue, Wen; Yi, Guohua; Zhou, Jiangbing

Clathrin packets move in slow axonal transport and deliver functional payloads to synapses

网格蛋白包在轴突内缓慢移动,并将功能性有效载荷递送至突触。

Archan Ganguly,Rohan Sharma,Nicholas P Boyer,Florian Wernert,Sébastien Phan,Daniela Boassa,Leonardo Parra,Utpal Das,Ghislaine Caillol,Xuemei Han,John R Yates 3rd,Mark H Ellisman,Christophe Leterrier,Subhojit Roy

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

利用CRISPR/Cas9技术编辑APP C端可减弱β-切割并促进α-切割。

Jichao Sun ,Jared Carlson-Stevermer ,Utpal Das ,Minjie Shen ,Marion Delenclos ,Amanda M Snead ,So Yeon Koo ,Lina Wang ,Dianhua Qiao ,Jonathan Loi ,Andrew J Petersen ,Michael Stockton ,Anita Bhattacharyya ,Mathew V Jones ,Xinyu Zhao ,Pamela J McLean ,Andrew A Sproul ,Krishanu Saha ,Subhojit Roy

Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin

Hsc70 分子伴侣活性是突触蛋白胞浆慢轴突运输所必需的

Archan Ganguly, Xuemei Han, Utpal Das, Lina Wang, Jonathan Loi, Jichao Sun, Daniel Gitler, Ghislaine Caillol, Christophe Leterrier, John R Yates 3rd, Subhojit Roy

Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology

路易体痴呆患者海马α-突触核蛋白的增多会导致记忆障碍,并与病理扩散相一致

David H Adamowicz ,Subhojit Roy ,David P Salmon ,Douglas R Galasko ,Lawrence A Hansen ,Eliezer Masliah ,Fred H Gage

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway

可视化神经元中的 APP 和 BACE-1 近似值有助于深入了解淀粉样变性途径

Utpal Das, Lina Wang, Archan Ganguly, Junmi M Saikia, Steven L Wagner, Edward H Koo, Subhojit Roy

A dynamic formin-dependent deep F-actin network in axons

轴突中动态的依赖甲酸的深层F-肌动蛋白网络

Archan Ganguly, Yong Tang, Lina Wang, Kelsey Ladt, Jonathan Loi, Bénédicte Dargent, Christophe Leterrier, Subhojit Roy