日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial

一种用于治疗血脂异常的口服、肝脏限制性 LXR 反向激动剂:临床前开发和 I 期试验

Li, Xiaoxu; Benegiamo, Giorgia; Vijayakumar, Archana; Sroda, Natalie; Kimura, Masaki; Huss, Ryan S; Weng, Steve; Murakami, Eisuke; Kirby, Brian J; von Alvensleben, Giacomo V G; Kremoser, Claus; Gane, Edward J; Takebe, Takanori; Myers, Robert P; Subramanian, G Mani; Auwerx, Johan

Reversal of ACLF and ALF using whole blood extracorporeal system combining HLA-depleted liver organoids with granulocyte-monocyte apheresis

利用全血体外循环系统结合去除HLA的肝脏类器官和粒细胞-单核细胞分离术逆转急性肝衰竭(ACLF)和急性肝衰竭(ALF)。

Yamaguchi, Hitomi; Yoneyama, Yosuke; Ichimura, Kentaro; Ohtsu, Kanae; Soen, Mika; Moriya, Chiharu; Kumagai, Maki; Myers, Robert P; Subramanian, G Mani; Takebe, Takanori

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH.

ACMSD 抑制剂可纠正 MASLD/MASH 中的纤维化、炎症和 DNA 损伤

Liu Yasmine J, Kimura Masaki, Li Xiaoxu, Sulc Jonathan, Wang Qi, Rodríguez-López Sandra, Scantlebery Angelique M L, Strotjohann Keno, Gallart-Ayala Hector, Vijayakumar Archana, Myers Robert P, Ivanisevic Julijana, Houtkooper Riekelt H, Subramanian G Mani, Takebe Takanori, Auwerx Johan

Genetic deletion or pharmacological inhibition of acetyl-CoA carboxylase 2 enhances fatty acid oxidation and improves cardiac function and survival in the murine ATGL knockout model of severe heart failure.

基因敲除或药物抑制乙酰辅酶A羧化酶2可增强脂肪酸氧化,改善严重心力衰竭小鼠ATGL敲除模型的心脏功能和生存率

Usui Mai, Tsurekawa Yu, Ikehara Tatsuya, Shimazaki Atsuyuki, Vijayakumar Archana, Myers Robert P, Subramanian G Mani, Murakami Eisuke

Investigating the Relationship Between Rare Genetic Variants and Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease

研究罕见基因变异与儿童非酒精性脂肪肝疾病纤维化之间的关系

Wattacheril, Julia; Kleinstein, Sarah E; Shea, Patrick R; Wilson, Laura A; Subramanian, G Mani; Myers, Robert P; Lefkowitch, Jay; Behling, Cynthia; Xanthakos, Stavra A; Goldstein, David B

Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH

整合基于深度学习的组织病理学和转录组学,揭示了晚期非酒精性脂肪性肝炎(NASH)患者纤维化发生相关的关键基因。

Conway, Jake; Pouryahya, Maryam; Gindin, Yevgeniy; Pan, David Z; Carrasco-Zevallos, Oscar M; Mountain, Victoria; Subramanian, G Mani; Montalto, Michael C; Resnick, Murray; Beck, Andrew H; Huss, Ryan S; Myers, Robert P; Taylor-Weiner, Amaro; Wapinski, Ilan; Chung, Chuhan

A Machine Learning Approach Enables Quantitative Measurement of Liver Histology and Disease Monitoring in NASH

机器学习方法可实现非酒精性脂肪性肝炎(NASH)肝脏组织学定量测量和疾病监测。

Taylor-Weiner, Amaro; Pokkalla, Harsha; Han, Ling; Jia, Catherine; Huss, Ryan; Chung, Chuhan; Elliott, Hunter; Glass, Benjamin; Pethia, Kishalve; Carrasco-Zevallos, Oscar; Shukla, Chinmay; Khettry, Urmila; Najarian, Robert; Taliano, Ross; Subramanian, G Mani; Myers, Robert P; Wapinski, Ilan; Khosla, Aditya; Resnick, Murray; Montalto, Michael C; Anstee, Quentin M; Wong, Vincent Wai-Sun; Trauner, Michael; Lawitz, Eric J; Harrison, Stephen A; Okanoue, Takeshi; Romero-Gomez, Manuel; Goodman, Zachary; Loomba, Rohit; Beck, Andrew H; Younossi, Zobair M

DNA Methylation and Immune Cell Markers Demonstrate Evidence of Accelerated Aging in Patients with Chronic Hepatitis B Virus or Hepatitis C Virus, with or without Human Immunodeficienct Virus Co-infection

DNA甲基化和免疫细胞标志物表明,慢性乙型肝炎病毒或丙型肝炎病毒感染患者(无论是否合并人类免疫缺陷病毒感染)存在加速衰老的证据。

Gindin, Yevgeniy; Gaggar, Anuj; Lok, Anna S; Janssen, Harry L A; Ferrari, Carlo; Subramanian, G Mani; Jiang, Zhaoshi; Masur, Henry; Emmanuel, Benjamin; Poonia, Bhawna; Kottilil, Shyam

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis

外周血中的甲基化特征与原发性硬化性胆管炎患者的显著衰老加速和疾病进展相关

Trauner, Michael; Gindin, Yevgeniy; Jiang, Zhaoshi; Chung, Chuhan; Subramanian, G Mani; Myers, Robert P; Gulamhusein, Aliya; Kowdley, Kris V; Levy, Cynthia; Goodman, Zachary; Manns, Michael P; Muir, Andrew J; Bowlus, Christopher L

Durability of Hepatitis B Surface Antigen Loss With Nucleotide Analogue and Peginterferon Therapy in Patients With Chronic Hepatitis B

核苷酸类似物和聚乙二醇干扰素治疗慢性乙型肝炎患者乙型肝炎表面抗原清除的持久性

Lok, Anna S; Zoulim, Fabien; Dusheiko, Geoffrey; Chan, Henry L Y; Buti, Maria; Ghany, Marc G; Gaggar, Anuj; Yang, Jenny C; Wu, George; Flaherty, John F; Subramanian, G Mani; Locarnini, Stephen; Marcellin, Patrick