文献库，生知库 | 链接生命科学的每一步

日期影响因子

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer.

靶向 EGFR 配体 Epiregulin 的抗体药物偶联物在结直肠癌中表现出强大的抗肿瘤活性

期刊:Cancer Research

影响因子:16.6

doi:10.1158/0008-5472.CAN-24-0798

Jacob Joan, Anami Yasuaki, High Peyton C, Liang Zhengdong, Subramanian Shraddha, Ghosh Sukhen C, AghaAmiri Solmaz, Guernsey-Biddle Cara, Tran Ha, Rowe Julie, Azhdarinia Ali, Tsuchikama Kyoji, Carmon Kendra S

发表日期：2025

文献求助收藏

Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models

西妥昔单抗可增加 LGR5 表达，并增强 LGR5 靶向抗体药物偶联物在患者来源的结直肠癌模型中的疗效。

期刊:Cell Reports Medicine

影响因子:10.6

doi:10.1016/j.xcrm.2025.102363

High, Peyton C; Liang, Zhengdong; Guernsey-Biddle, Cara; Subramanian, Shraddha; Shyu, Yueh-Ming; Aldana, Adela M; Toh, Yukimatsu; Carmon, Kendra S

发表日期：2025

文献求助收藏

Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models.

西妥昔单抗可增加 LGR5 表达，并增强 LGR5 靶向抗体药物偶联物在患者来源的结直肠癌模型中的疗效

doi:10.1101/2025.06.18.660406

High Peyton C, Liang Zhengdong, Guernsey-Biddle Cara, Subramanian Shraddha, Shyu Yueh-Ming, Aldana Adela M, Toh Yukimatsu, Carmon Kendra S

发表日期：2025

文献求助收藏

The Evolving Paradigm of Antibody-Drug Conjugates Targeting the ErbB/HER Family of Receptor Tyrosine Kinases

靶向ErbB/HER受体酪氨酸激酶家族的抗体-药物偶联物范式演变

期刊:Pharmaceutics

影响因子:5.5

doi:10.3390/pharmaceutics16070890

High, Peyton; Guernsey, Cara; Subramanian, Shraddha; Jacob, Joan; Carmon, Kendra S

发表日期：2024

文献求助收藏

An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer.

针对 GPR56 的抗体药物偶联物在结直肠癌的临床前模型中显示出疗效

期刊:British Journal of Cancer

影响因子:6.8

doi:10.1038/s41416-023-02192-3

Jacob Joan, Francisco Liezl E, Chatterjee Treena, Liang Zhengdong, Subramanian Shraddha, Liu Qingyun J, Rowe Julie H, Carmon Kendra S

发表日期：2023

文献求助收藏