日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

作者更正:Sin1 磷酸化损害 mTORC2 复合物的完整性并抑制下游 Akt 信号传导以抑制肿瘤发生

Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao, Omotooke Arojo, Dou Liu, Lixin Wan, Bo Zhai, Yonghao Yu, Min Yuan, Byeong Mo Kim, Shavali Shaik, Suchithra Menon, Steven P Gygi, Tae Ho Lee, John M Asara, Brendan D Manning, John Blenis, Bing Su, Wenyi Wei

Bile acid analogues are activators of pyrin inflammasome

胆汁酸类似物是吡啶炎症小体的激活剂

Irina Alimov, Suchithra Menon, Nadire Cochran, Rob Maher, Qiong Wang, John Alford, John B Concannon, Zinger Yang, Edmund Harrington, Luis Llamas, Alicia Lindeman, Gregory Hoffman, Tim Schuhmann, Carsten Russ, John Reece-Hoyes, Stephen M Canham, Xinming Cai

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

TSC 复合物的空间控制整合了溶酶体中 mTORC1 的胰岛素和营养调节

Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

选择性 VPS34 抑制剂阻断自噬并揭示 NCOA4 在体内铁蛋白降解和铁稳态中的作用

William E Dowdle, Beat Nyfeler, Jane Nagel, Robert A Elling, Shanming Liu, Ellen Triantafellow, Suchithra Menon, Zuncai Wang, Ayako Honda, Gwynn Pardee, John Cantwell, Catherine Luu, Ivan Cornella-Taracido, Edmund Harrington, Peter Fekkes, Hong Lei, Qing Fang, Mary Ellen Digan, Debra Burdick, Andrew

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

TBC1D7 是 mTORC1 上游 TSC1-TSC2 复合物的第三个亚基

Christian C Dibble, Winfried Elis, Suchithra Menon, Wei Qin, Justin Klekota, John M Asara, Peter M Finan, David J Kwiatkowski, Leon O Murphy, Brendan D Manning

Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice

mTOR 复合物 1 的慢性激活足以导致小鼠肝细胞癌

Suchithra Menon, Jessica L Yecies, Hui H Zhang, Jessica J Howell, Justin Nicholatos, Eylul Harputlugil, Roderick T Bronson, David J Kwiatkowski, Brendan D Manning