日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model

强效预组织吡唑烷环孢素D抑制剂可预防小鼠胰腺炎疾病模型中的线粒体和器官损伤

Awais, Muhammad; Woodley, Christopher M; Guo, Liqun; Rogers, Michael; Kershaw, Neil; Zacharchenko, Thomas; Shore, Emma; Kattakayam, Arjun; Mukherjee, Rajarshi; Criddle, David N; Leung, Suet C; Lee, Heather; Burgess-McCann, Joshua; Luzyanin, Konstantin; Berry, Neil G; Antonyuk, Svetlana; Lian, Lu-Yun; Sutton, Robert; O'Neill, Paul M

Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum

设计、合成和建模光反应化学探针,用于研究恶性疟原虫中疟原虫蛋白酶IX和X的靶标结合

Lisauskaitė, Monika; Nixon, Gemma L; Woodley, Christopher M; Berry, Neil G; Coninckx, Andy; Qie, L Charlie; Leung, Suet C; Taramelli, Donatella; Basilico, Nicoletta; Parapini, Silvia; Ward, Stephen A; Vadas, Oscar; Soldati-Favre, Dominique; Hong, W David; O'Neill, Paul M

Targeting the Ubiquinol-Reduction (Q(i)) Site of the Mitochondrial Cytochrome bc(1) Complex for the Development of Next Generation Quinolone Antimalarials

靶向线粒体细胞色素bc(1)复合物的泛醌还原(Q(i))位点以开发下一代喹诺酮类抗疟药

Amporndanai, Kangsa; Pinthong, Nattapon; O'Neill, Paul M; Hong, W David; Amewu, Richard K; Pidathala, Chandrakala; Berry, Neil G; Leung, Suet C; Ward, Stephen A; Biagini, Giancarlo A; Hasnain, S Samar; Antonyuk, Svetlana V

3T-MRI-based age, sex and site-specific markers of musculoskeletal health in healthy children and young adults

基于3T磁共振成像的健康儿童和青少年肌肉骨骼健康的年龄、性别和部位特异性标志物

Elsharkasi, Huda M; Chen, Suet C; Steell, Lewis; Joseph, Shuko; Abdalrahaman, Naiemh; McComb, Christie; Johnston, Blair; Foster, John; Wong, Sze Choong; Faisal Ahmed, S

Potent Antimalarial 2-Pyrazolyl Quinolone bc (1) (Q(i)) Inhibitors with Improved Drug-like Properties

具有改进的类药性的强效抗疟疾2-吡唑基喹诺酮bc(1)(Q(i))抑制剂

David Hong, W; Leung, Suet C; Amporndanai, Kangsa; Davies, Jill; Priestley, Richard S; Nixon, Gemma L; Berry, Neil G; Samar Hasnain, S; Antonyuk, Svetlana; Ward, Stephen A; Biagini, Giancarlo A; O'Neill, Paul M

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.

开发针对恶性疟原虫线粒体呼吸链的喹诺酮类抗疟药,用于治疗和预防疟疾

Biagini Giancarlo A, Fisher Nicholas, Shone Alison E, Mubaraki Murad A, Srivastava Abhishek, Hill Alisdair, Antoine Thomas, Warman Ashley J, Davies Jill, Pidathala Chandrakala, Amewu Richard K, Leung Suet C, Sharma Raman, Gibbons Peter, Hong David W, Pacorel Bénédicte, Lawrenson Alexandre S, Charoensutthivarakul Sitthivut, Taylor Lee, Berger Olivier, Mbekeani Alison, Stocks Paul A, Nixon Gemma L, Chadwick James, Hemingway Janet, Delves Michael J, Sinden Robert E, Zeeman Anne-Marie, Kocken Clemens H M, Berry Neil G, O'Neill Paul M, Ward Stephen A

Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2)

针对恶性疟原虫 II 型 NADH:醌氧化还原酶 (PfNDH2) 的杂环喹诺酮的鉴定、设计和生物学评价

Leung, Suet C; Gibbons, Peter; Amewu, Richard; Nixon, Gemma L; Pidathala, Chandrakala; Hong, W David; Pacorel, Bénédicte; Berry, Neil G; Sharma, Raman; Stocks, Paul A; Srivastava, Abhishek; Shone, Alison E; Charoensutthivarakul, Sitthivut; Taylor, Lee; Berger, Olivier; Mbekeani, Alison; Hill, Alasdair; Fisher, Nicholas E; Warman, Ashley J; Biagini, Giancarlo A; Ward, Stephen A; O'Neill, Paul M