Implementation of Metformin Therapy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD): study protocol for a phase III, multi-centre, randomized, placebo-controlled trial evaluating the long-term efficacy of metformin in slowing the rate of kidney function decline in patients with autosomal dominant polycystic kidney disease
二甲双胍治疗延缓多囊肾病肾功能下降的研究方案（IMPEDE-PKD）：一项评估二甲双胍长期疗效的III期、多中心、随机、安慰剂对照试验，旨在评估二甲双胍在延缓常染色体显性多囊肾病患者肾功能下降速度方面的疗效。
期刊:Trials
影响因子:2
doi:10.1186/s13063-025-09010-6
Pierre, Kitty St; El-Damanawi, Ragada; Johnson, David W; Hawley, Carmel M; Viecelli, Andrea K; Jha, Vivekanand; Green, Suetonia C; Gesualdo, Loreto; Kiriwandeniya, Charani; Velayudham, Pushparaj; Vergara, Liza A; Mihala, Gabor; Matsuyama, Misa; Brent, Peta-Ann Paul; Mallett, Andrew J
