MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma
MEK 抑制剂 PD-0325901 克服了对 PI3K/mTOR 抑制剂 PF-5212384 的耐药性,并增强了对人类头颈部鳞状细胞癌的抗肿瘤作用
期刊:Clinical Cancer Research
影响因子:10
doi:10.1158/1078-0432.CCR-14-3377
Suresh Mohan, Robert Vander Broek, Sujay Shah, Danielle F Eytan, Matthew L Pierce, Sophie G Carlson, Jamie F Coupar, Jialing Zhang, Hui Cheng, Zhong Chen, Carter Van Waes
信号转导
肿瘤
头颈癌
其它细胞
PI3K/Akt
mTOR
Human