日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses

INBRX-120 是一种靶向 CD8α 的失谐 IL-2,可选择性扩增和激活杀肿瘤效应细胞,从而实现安全持久的体内反应

Florian J Sulzmaier, Nadja Kern, Sae Jeong Ahn, Anya Polovina, Jason Ho, Abrahim Hussain, Garrett Cyprus, Chelsie Macedo, Rajay Pandit, William Crago, Emily Rowell, John C Timmer, Brendan P Eckelman

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

FAK活性维持卵巢癌对铂类化疗的固有耐药性和获得性耐药性

Carlos J Diaz Osterman #,Duygu Ozmadenci #,Elizabeth G Kleinschmidt #,Kristin N Taylor #,Allison M Barrie #,Shulin Jiang #,Lisa M Bean #,Florian J Sulzmaier #,Christine Jean,Isabelle Tancioni,Kristen Anderson,Sean Uryu,Edward A Cordasco,Jian Li,Xiao Lei Chen,Guo Fu,Marjaana Ojalill,Pekka Rappu,Jyrki Heino,Adam M Mark,Guorong Xu,Kathleen M Fisch,Vihren N Kolev,David T Weaver,Jonathan A Pachter,Balázs Győrffy,Michael T McHale,Denise C Connolly,Alfredo Molinolo,Dwayne G Stupack,David D Schlaepfer

Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression

氧化 LDL 诱导 FAK 依赖性 RSK 信号传导,从而驱动 NF-κB 活化和 VCAM-1 表达

Arif Yurdagul Jr, Florian J Sulzmaier, Xiao L Chen, Christopher B Pattillo, David D Schlaepfer, A Wayne Orr

Synthesis of a stable and orally bioavailable englerin analogue

合成一种稳定且口服生物利用度高的恩格林类似物

Fash, David M; Peer, Cody J; Li, Zhenwu; Talisman, Ian J; Hayavi, Sima; Sulzmaier, Florian J; Ramos, Joe W; Sourbier, Carole; Neckers, Leonard; Figg, W Douglas; Beutler, John A; Chain, William J

RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics

RSK2 活性介导胶质母细胞瘤侵袭性,是新疗法的潜在靶点

Florian J Sulzmaier, Shirley Young-Robbins, Pengfei Jiang, Dirk Geerts, Amanda M Prechtl, Michelle L Matter, Santosh Kesari, Joe W Ramos

Neopetrocyclamines A and B, polycyclic diamine alkaloids from the sponge Neopetrosia cf exigua

新石环胺A和B,来自海绵Neopetrosia cf exigua的多环二胺生物碱

Liang, Zhibin; Sulzmaier, Florian J; Yoshida, Wesley Y; Kelly, Michelle; Ramos, Joe W; Williams, Philip G

FAK in cancer: mechanistic findings and clinical applications

FAK在癌症中的作用:机制研究及临床应用

Sulzmaier, Florian J; Jean, Christine; Schlaepfer, David D

FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth

FAK抑制会破坏控制卵巢癌细胞非依赖性生长的β5整合素信号通路。

Tancioni, Isabelle; Uryu, Sean; Sulzmaier, Florian J; Shah, Nina R; Lawson, Christine; Miller, Nichol L G; Jean, Christine; Chen, Xiao Lei; Ward, Kristy K; Schlaepfer, David D

Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer

merlin/NF2 与浆液性卵巢癌 FAK 抑制剂反应性的关联分析

Nina R Shah, Isabelle Tancioni, Kristy K Ward, Christine Lawson, Xiao Lei Chen, Christine Jean, Florian J Sulzmaier, Sean Uryu, Nichol L G Miller, Denise C Connolly, David D Schlaepfer

Organometallic Titanocene-Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein Kinase Inhibitory Properties

有机金属钛茂-金化合物作为肾癌潜在化疗药物的研究:其蛋白激酶抑制特性的研究

Fernández-Gallardo, Jacob; Elie, Benelita T; Sulzmaier, Florian J; Sanaú, Mercedes; Ramos, Joe W; Contel, María