日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis

致癌突变 p53 通过氧化应激依赖性诱导线粒体凋亡使非小细胞肺癌细胞对蛋白酶体抑制敏感

Kranthi Kumar Chougoni #, Victoria Neely #, Boxiao Ding, Eziafa Oduah, Vianna T Lam, Bin Hu, Jennifer E Koblinski, Bradford E Windle, Swati Palit Deb, Sumitra Deb, Jorge J Nieva, Senthil K Radhakrishnan, Hisashi Harada, Steven R Grossman

Targeting Oncogenic Mutant p53 and BCL-2 for Small Cell Lung Cancer Treatment

针对致癌突变 p53 和 BCL-2 治疗小细胞肺癌

Victoria Neely, Alekhya Manchikalapudi, Khanh Nguyen, Krista Dalton, Bin Hu, Jennifer E Koblinski, Anthony C Faber, Sumitra Deb, Hisashi Harada

The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3

肿瘤衍生的突变 p53 的致癌性因 PLK3 的募集而增强

Catherine A Vaughan, Shilpa Singh, Mark A Subler, Jolene J Windle, Kazushi Inoue, Elizabeth A Fry, Raghavendra Pillappa, Steven R Grossman, Brad Windle, W Andrew Yeudall, Swati Palit Deb, Sumitra Deb

DNA replication in progenitor cells and epithelial regeneration after lung injury requires the oncoprotein MDM2

祖细胞中的 DNA 复制和肺损伤后的上皮再生需要癌蛋白 MDM2

Shilpa Singh, Catherine A Vaughan, Christopher Rabender, Ross Mikkelsen, Sumitra Deb, Swati Palit Deb

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication

突变 p53 通过促进非计划复制建立可靶向的肿瘤依赖性

Shilpa Singh, Catherine A Vaughan, Rebecca A Frum, Steven R Grossman, Sumitra Deb, Swati Palit Deb

Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells

获得功能 p53 激活多种信号通路,诱导肺癌细胞致癌性

Catherine A Vaughan, Shilpa Singh, Steven R Grossman, Brad Windle, Swati Palit Deb, Sumitra Deb

Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter

表皮生长因子受体通过与 p53 转录激活域和启动子的多次接触上调,促进肺癌细胞对 GOF p53 的依赖

Catherine A Vaughan, Isabella Pearsall, Shilpa Singh, Brad Windle, Swati P Deb, Steven R Grossman, W Andrew Yeudall, Sumitra Deb

Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites

获得功能突变 p53 优先与双向启动子结合,ETS1 和 GABPA 协同与多个结合位点结合

Catherine A Vaughan, Swati P Deb, Sumitra Deb, Brad Windle

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation

ATM 激酶抑制优先使 p53 突变型胶质瘤对电离辐射敏感

Laura Biddlestone-Thorpe, Muhammad Sajjad, Elizabeth Rosenberg, Jason M Beckta, Nicholas C K Valerie, Mary Tokarz, Bret R Adams, Alison F Wagner, Ashraf Khalil, Donna Gilfor, Sarah E Golding, Sumitra Deb, David G Temesi, Alan Lau, Mark J O'Connor, Kevin S Choe, Luis F Parada, Sang Kyun Lim, Nitai D

Use of the DNA fiber spreading technique to detect the effects of mutant p53 on DNA replication

利用DNA纤维铺展技术检测突变型p53对DNA复制的影响

Frum, Rebecca A; Deb, Sumitra; Deb, Swati Palit