日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

在随机临床试验中,研究性 eIF2B 激活剂 DNL343 可调节 TDP-43 病理临床前模型和 ALS 患者的整合应激反应。

Brittany N Flores # ,Seungyoon B Yu # ,Isaac V Cohen # ,Melania H Fanok # ,Wei Luan ,Romeo D Maciuca ,Linus D Sun ,Richard M Tsai ,Maurits Vissers ,Lars Smits ,Tommy M Bunte ,Anna Bakardjiev ,Srijana Balasundar ,Meredith E K Calvert ,Marcus Y Chin ,Sarah K Dobbins ,William E Dowdle ,Meng Fang ,Jules A A C Heuberger ,Connie L Ha ,Fen Huang ,Takashi Miyamoto ,Maksim Osipov ,Lidia Madrid San Martin ,Katie Saund ,David Tatarakis ,Anthony Q Vu ,Chenling Xiong ,Gene W Yeo ,Geert Jan Groeneveld ,Leonard H van den Berg ,Shyeilla Dhuria ,Anthony A Estrada ,Danna Jennings ,Thomas Sandmann ,Carole Ho ,Kimberly Scearce-Levie ,Ernie Yulyaningsih ,Adam K Walker ,Gilbert Di Paolo ,Lesley A Kane ,Matthew D Troyer ,Joseph W Lewcock

Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD).

发现帕拉塞斯特兰(OP-1250),一种强效且口服生物利用度高的完全雌激素受体拮抗剂(CERAN)和选择性雌激素受体降解剂(SERD)

Ng Raymond A, Barratt Susanna, Parisian Alison, Palanisamy Gopinath S, Phukan Samiron, Sun Richard, Robello Brandon, Peña Guadalupe, Sapugay Judevin, Yeghikyan David, Wang Chenbo, Satish Kher Samir, Thangathirupathy Srinivasan, Millikin Robert, Yu Guijun, Watanabe Teruki, Zhou Fei, Rich Brian, Duncan Alexis, Andersen Samuel E, Chawla Reena, Zak David R, Heerding Dirk A, Hearn Brian R, Greene Geoffrey, Harmon Cyrus L, Hodges-Gallagher Leslie, Kushner Peter J, Fanning Sean W, Myles David C

OLTA: Optimizing bait seLection for TArgeted sequencing

OLTA:优化靶向测序的诱饵选择

Minbay, Mete Orhun; Sun, Richard; Ramachandran, Vijay; Ay, Ahmet; Kahveci, Tamer

Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity

干扰素反应和SMARCA4突变引起的表观遗传调控驱动卵巢肿瘤免疫原性

Melica Nourmoussavi Brodeur ,Higinio Dopeso ,Yingjie Zhu ,Ana Leda F Longhini ,Andrea Gazzo ,Siyu Sun ,Richard P Koche ,Rui Qu ,Laura Rosenberg ,Pierre-Jacques Hamard ,Yonina Bykov ,Hunter Green ,Laxmi Gusain ,Katherine B Chiappinelli ,Melih Arda Ozsoy ,M Herman Chui ,Thais Basili ,Rui Gardner ,Sven Walderich ,Elisa DeStanchina ,Benjamin Greenbaum ,Mithat Gönen ,Nicolas Vabret ,Britta Weigelt ,Dmitriy Zamarin

Magnetically driven formation of 3D freestanding soft bioscaffolds

磁驱动形成三维独立软生物支架

Ruoxiao Xie, Yuanxiong Cao, Rujie Sun, Richard Wang, Alexis Morgan, Junyoung Kim, Sebastien J P Callens, Kai Xie, Jiawen Zou, Junliang Lin, Kun Zhou, Xiangrong Lu, Molly M Stevens

Large language models generate functional protein sequences across diverse families

大型语言模型可生成跨不同家族的功能性蛋白质序列

Ali Madani, Ben Krause #, Eric R Greene #, Subu Subramanian, Benjamin P Mohr, James M Holton, Jose Luis Olmos Jr, Caiming Xiong, Zachary Z Sun, Richard Socher, James S Fraser, Nikhil Naik1

[11C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue

[11C]卡芬太尼 PET 成像用于研究体内外周阿片类药物系统:光周期对棕色脂肪组织中 μ-阿片受体可用性的影响

Lihua Sun, Richard Aarnio, Erika Atencio Herre, Salli Kärnä, Senthil Palani, Helena Virtanen, Heidi Liljenbäck, Jenni Virta, Aake Honkaniemi, Vesa Oikonen, Chunlei Han, Sanna Laurila, Marco Bucci, Semi Helin, Emrah Yatkin, Lauri Nummenmaa, Pirjo Nuutila, Jing Tang, Anne Roivainen

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling

通过治疗性阻断IL-6信号通路可以降低与COVID-19严重程度相关的髓系程序。

Jason A Hackney ,Haridha Shivram ,Jason Vander Heiden ,Chris Overall ,Luz Orozco ,Xia Gao ,Eugene Kim ,Nathan West ,Aditi Qamra ,Diana Chang ,Arindam Chakrabarti ,David F Choy ,Alexis J Combes ,Tristan Courau ,Gabriela K Fragiadakis ,Arjun Arkal Rao ,Arja Ray ,Jessica Tsui ,Kenneth Hu ,Nicholas F Kuhn ,Matthew F Krummel ,David J Erle ,Kirsten Kangelaris ,Aartik Sarma ,Zoe Lyon ,Carolyn S Calfee ,Prescott G Woodruff ,Rajani Ghale ,Eran Mick ,Ashley Byrne ,Beth Shoshana Zha ,Charles Langelier ,Carolyn M Hendrickson ,Monique G P van der Wijst ,George C Hartoularos ,Tianna Grant ,Raymund Bueno ,David S Lee ,John R Greenland ,Yang Sun ,Richard Perez ,Anton Ogorodnikov ,Alyssa Ward ,Chun Jimmie Ye ,Jacqueline M McBride ,Fang Cai ,Anastasia Teterina ,Min Bao ,Larry Tsai ,Ivan O Rosas ,Aviv Regev ,Sharookh B Kapadia ,Rebecca N Bauer ,Carrie M Rosenberger

Neonatal and adult cardiac fibroblasts exhibit inherent differences in cardiac regenerative capacity

新生儿和成人心脏成纤维细胞在心脏再生能力方面表现出内在差异

Hualing Sun, Richard E Pratt, Victor J Dzau, Conrad P Hodgkinson

RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells

RTK信号通路促进人肺祖细胞上皮柱状细胞形态和顶端连接的维持

Shuyu Liu,Dawei Sun,Richard Butler,Emma L Rawlins