日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Neuroprotective and intraocular pressure lowering effects of dual-functional memantine nitrate MN-08 on the experimental models of glaucoma.

双功能硝酸美金刚MN-08对青光眼实验模型的神经保护和降低眼内压作用

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-06832-x
Hu Huihui, Wu Liangmiao, Hu Xiaodie, Wang Minghua, Sun Yewei, Zhang Gaoxiao, Wang Yuqiang, Yi Peng, Zhang Zaijun
神经科学
发表日期：2025
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Therapeutic efficacy of novel memantine nitrate MN-08 in animal models of Alzheimer's disease

新型硝酸美金刚MN-08在阿尔茨海默病动物模型中的治疗效果

期刊:Aging Cell
影响因子:7.1
doi:10.1111/acel.13371
Wu, Liangmiao; Zhou, Xinhua; Cao, Yiwan; Mak, Shing Hung; Zha, Ling; Li, Ning; Su, Zhiyang; Han, Yifan; Wang, Yuqiang; Man Hoi, Maggie Pui; Sun, Yewei; Zhang, Gaoxiao; Zhang, Zaijun; Yang, Xifei
阿尔茨海默症
发表日期：2021
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Neuroprotective and neurogenic effects of novel tetramethylpyrazine derivative T-006 in Parkinson's disease models through activating the MEF2-PGC1α and BDNF/CREB pathways

新型四甲基吡嗪衍生物T-006通过激活MEF2-PGC1α和BDNF/CREB通路在帕金森病模型中发挥神经保护和神经发生作用

期刊:Aging-Us
影响因子:3.9
doi:10.18632/aging.103551
Chen, Haiyun; Cao, Jie; Zha, Ling; Wang, Peile; Liu, Zheng; Guo, Baojian; Zhang, Gaoxiao; Sun, Yewei; Zhang, Zaijun; Wang, Yuqiang
信号转导
帕金森
神经科学
CREB
BDNF
发表日期：2020
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Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post-ischaemic neuroregeneration and recovery of neurological functions in rats

四甲基吡嗪硝酮激活BDNF/Akt/CREB通路，促进大鼠缺血后神经再生和神经功能恢复。

期刊:British Journal of Pharmacology
影响因子:7.7
doi:10.1111/bph.14102
Zhang, Gaoxiao; Zhang, Tao; Li, Ning; Wu, Liangmiao; Gu, Jianbo; Li, Cuimei; Zhao, Chen; Liu, Wei; Shan, Luchen; Yu, Pei; Yang, Xifei; Tang, Yaohui; Yang, Guo-Yuan; Wang, Yuqiang; Sun, Yewei; Zhang, Zaijun
BDNF
信号转导
CREB
Rat
发表日期：2018
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A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways

一种新型四甲基吡嗪衍生物通过PGC1α/Nrf2和PI3K/Akt信号通路抵抗谷氨酸诱导的细胞毒性

期刊:Frontiers in Neuroscience
影响因子:3.2
doi:10.3389/fnins.2018.00567
Chen, Haiyun; Cao, Jie; Zhu, Zeyu; Zhang, Gaoxiao; Shan, Luchen; Yu, Pei; Wang, Yuqiang; Sun, Yewei; Zhang, Zaijun
PI3K/Akt
发表日期：2018
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Synthesis and biological evaluation of memantine nitrates as a potential treatment for neurodegenerative diseases

合成和生物学评价硝酸美金刚作为治疗神经退行性疾病的潜在药物

期刊:Medchemcomm
影响因子:
doi:10.1039/c6md00509h
Liu, Zheng; Yang, Si; Jin, Xiaoyong; Zhang, Gaoxiao; Guo, Baojian; Chen, Haiyun; Yu, Pei; Sun, Yewei; Zhang, Zaijun; Wang, Yuqiang
神经科学
发表日期：2017
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Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy

四甲基吡嗪硝酮是一种用于缺血性中风治疗的多功能神经保护剂

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/srep37148
Zhang, Zaijun; Zhang, Gaoxiao; Sun, Yewei; Szeto, Samuel S W; Law, Henry C H; Quan, Quan; Li, Guohui; Yu, Pei; Sho, Eiketsu; Siu, Michael K W; Lee, Simon M Y; Chu, Ivan K; Wang, Yuqiang
中风
心血管
发表日期：2016
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Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury

依达拉奉对碘乙酸诱导的小脑颗粒神经元原代损伤的保护作用

期刊:Oxidative Medicine and Cellular Longevity
影响因子:
doi:10.1155/2015/606981
Zhou, Xinhua; Zhu, Longjun; Wang, Liang; Guo, Baojian; Zhang, Gaoxiao; Sun, Yewei; Zhang, Zaijun; Lee, Simon Ming-Yuen; Yu, Pei; Wang, Yuqiang
神经科学
发表日期：2015
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