日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops

肺炎克雷伯菌碳青霉烯酶变体44通过改变活性位点环的构象获得头孢他啶-阿维巴坦耐药性

Sun, Zhizeng; Lin, Hanfeng; Hu, Liya; Neetu, Neetu; Sankaran, Banumathi; Wang, Jin; Prasad, B V Venkataram; Palzkill, Timothy

Evaluation of Tebipenem Hydrolysis by β-Lactamases Prevalent in Complicated Urinary Tract Infections

评估β-内酰胺酶对替比培南在复杂性尿路感染中的水解作用

Sun, Zhizeng; Su, Lynn; Cotroneo, Nicole; Critchley, Ian; Pucci, Michael; Jain, Akash; Palzkill, Timothy

Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1

深度突变扫描揭示了粘菌素抗生素耐药酶 MCR-1 的活性位点序列要求

Sun, Zhizeng; Palzkill, Timothy

Streptococcus pyogenes genes that promote pharyngitis in primates

链球菌中促进灵长类动物咽炎的基因

Zhu, Luchang; Olsen, Randall J; Beres, Stephen B; Saavedra, Matthew Ojeda; Kubiak, Samantha L; Cantu, Concepcion C; Jenkins, Leslie; Waller, Andrew S; Sun, Zhizeng; Palzkill, Timothy; Porter, Adeline R; DeLeo, Frank R; Musser, James M

Synergistic effects of functionally distinct substitutions in β-lactamase variants shed light on the evolution of bacterial drug resistance

β-内酰胺酶变体中功能不同的氨基酸替换的协同效应揭示了细菌耐药性的进化机制

Patel, Meha P; Hu, Liya; Brown, Cameron A; Sun, Zhizeng; Adamski, Carolyn J; Stojanoski, Vlatko; Sankaran, Banumathi; Prasad, B V Venkataram; Palzkill, Timothy

Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-β-Lactamase is Fragile to Mutations

随机突变体库的深度测序揭示了窄特异性CphA金属β-内酰胺酶的活性位点对突变的脆弱性

Sun, Zhizeng; Mehta, Shrenik C; Adamski, Carolyn J; Gibbs, Richard A; Palzkill, Timothy

Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion

WDR26 的上调作为支架蛋白,协调 PI3K/AKT 通路驱动的乳腺癌细胞生长、迁移和侵袭。

Ye, Yuanchao; Tang, Xiaoyun; Sun, Zhizeng; Chen, Songhai

Cerecidins, novel lantibiotics from Bacillus cereus with potent antimicrobial activity

Cerecidins 是一种来自蜡状芽孢杆菌的新型羊毛硫抗生素,具有强效抗菌活性

Jian Wang, Li Zhang, Kunling Teng, Shutao Sun, Zhizeng Sun, Jin Zhong

The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration.

WD40 重复蛋白WDR26 结合Gβγ 并促进Gβγ 依赖性信号转导和白细胞迁移

Sun Zhizeng, Tang Xiaoyun, Lin Fang, Chen Songhai