PIEZO1 gain-of-function mutation drives cardiomyopathy by disrupting myocardial lipid homeostasis besides iron overload.
PIEZO1 功能获得性突变除了导致铁过载外,还会破坏心肌脂质稳态,从而引发心肌病。
期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.ady9242
Fan Cuiqin, Du Han, Sun Song, Lu Huixia, Wang Yanming, Lu Fujian, Wang Qian, Zhang Cheng, Xue Li, Pan Chang, Yue Hongwei, Wang Hao, Qian Juying, Cui Sumei, Chen Yuguo, Xu Feng