Knockdown of TOP2A reverses cisplatin resistance in ovarian cancer by inhibiting EMT via ferroptosis mediated by the TP53/GPX4/SLC7A11 axis.
敲除 TOP2A 可逆转卵巢癌的顺铂耐药性,其机制是通过 TP53/GPX4/SLC7A11 轴介导的铁死亡抑制 EMT。
期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2025.1675373
Liu Xinyue, Wang Junxia, Liu Yangyu, Han Yan, Qin Zhichao, Wang Yu, Gao Shanxiang, Li Xinghua, Suo Yuping