日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase I Study of Adavosertib with Radiotherapy and Temozolomide in Newly Diagnosed Glioblastoma and Intratumoral Drug Levels in Recurrent Glioblastoma

阿达沃塞替尼联合放疗和替莫唑胺治疗新诊断胶质母细胞瘤的I期研究及复发性胶质母细胞瘤的肿瘤内药物浓度

Lee, Eudocia Q; Alexander, Brian M; Romo, Carlos G; Supko, Jeffrey G; Agar, Nathalie Y R; Talebi, Zahra; Ahluwalia, Manmeet S; Desai, Arati S; Dietrich, Jorg; Kaley, Thomas J; Peereboom, David M; Gantchev, Jennifer; Baquer, Gerard; Santagata, Sandro; Takebe, Naoko; Desideri, Serena; Fisher, Joy D; Sims, Megan; Ye, Xiaobu; Ligon, Keith L; Nabors, Louis B; Grossman, Stuart A; Wen, Patrick Y

Combined PARP and HSP90 inhibition: preclinical and Phase 1 evaluation in patients with advanced solid tumours

PARP 和 HSP90 联合抑制:晚期实体瘤患者的临床前和 I 期评估

Konstantinopoulos, Panagiotis A; Cheng, Su-Chun; Supko, Jeffrey G; Polak, Madeline; Wahner-Hendrickson, Andrea E; Ivy, S Percy; Bowes, Brittany; Sawyer, Hannah; Basada, Patrice; Hayes, Martin; Curtis, Jennifer; Horowitz, Neil; Wright, Alexi A; Campos, Susana M; Ivanova, Elena V; Paweletz, Cloud P; Palakurthi, Sangeetha; Liu, Joyce F; D'Andrea, Alan D; Gokhale, Prafulla C; Chowdhury, Dipanjan; Matulonis, Ursula A; Shapiro, Geoffrey I

Severe Lactic Acidosis Complicated by Insulin-Resistant Hyperosmolar Hyperglycemic Syndrome in a Patient With Metastatic Breast Cancer Undergoing AKT-Inhibitor Therapy

接受AKT抑制剂治疗的转移性乳腺癌患者出现严重的乳酸性酸中毒,并伴有胰岛素抵抗性高渗性高血糖综合征。

Stamou, Maria I; Chen, Christopher; Wander, Seth A; Supko, Jeffrey G; Juric, Dejan; Bardia, Aditya; Wexler, Deborah J

Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses

靶向治疗慢性淋巴细胞白血病中组成型激活的STAT3:STAT3抑制剂乙胺嘧啶的临床试验及药效学分析

Brown, Jennifer R; Walker, Sarah R; Heppler, Lisa N; Tyekucheva, Svitlana; Nelson, Erik A; Klitgaard, Josephine; Nicolais, Maria; Kroll, Yasmin; Xiang, Michael; Yeh, Jennifer E; Chaudhury, Mousumi; Giaccone, Zachary T; Fernandes, Stacey M; Jacobsen, Eric D; Fisher, David C; Freedman, Arnold S; Davids, Matthew S; Supko, Jeffrey G; Wu, Catherine; Frank, David A

Phase 1b clinical trial of ado-trastuzumab emtansine and ribociclib for HER2-positive metastatic breast cancer

ado-trastuzumab emtansine 和 ribociclib 治疗 HER2 阳性转移性乳腺癌的 1b 期临床试验

Spring, Laura M; Clark, Shealagh L; Li, Tianyu; Goel, Shom; Tayob, Nabihah; Viscosi, Elene; Abraham, Elizabeth; Juric, Dejan; Isakoff, Steven J; Mayer, Erica; Moy, Beverly; Supko, Jeffrey G; Tolaney, Sara M; Bardia, Aditya

Dual Blockade of c-MET and the Androgen Receptor in Metastatic Castration-resistant Prostate Cancer: A Phase I Study of Concurrent Enzalutamide and Crizotinib

转移性去势抵抗性前列腺癌中 c-MET 和雄激素受体的双重阻断:恩扎卢胺和克唑替尼联合治疗的 I 期研究

Tripathi, Abhishek; Supko, Jeffrey G; Gray, Kathryn P; Melnick, Zachary J; Regan, Meredith M; Taplin, Mary-Ellen; Choudhury, Atish D; Pomerantz, Mark M; Bellmunt, Joaquim; Yu, Channing; Sun, Zijie; Srinivas, Sandy; Kantoff, Philip W; Sweeney, Christopher J; Harshman, Lauren C

Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors

HSP90抑制剂onalespib联合泛CDK抑制剂AT7519治疗晚期实体瘤患者的I期研究

Do, Khanh T; O'Sullivan Coyne, Geraldine; Hays, John L; Supko, Jeffrey G; Liu, Stephen V; Beebe, Kristin; Neckers, Len; Trepel, Jane B; Lee, Min-Jung; Smyth, Tomoko; Gannon, Courtney; Hedglin, Jennifer; Muzikansky, Alona; Campos, Susana; Lyons, John; Ivy, Percy; Doroshow, James H; Chen, Alice P; Shapiro, Geoffrey I

Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model

利用声反馈技术,临床聚焦超声系统能够安全可靠地将卡铂输送穿过血脑屏障,并提高大鼠胶质瘤模型的生存率。

McDannold, Nathan; Zhang, Yongzhi; Supko, Jeffrey G; Power, Chanikarn; Sun, Tao; Peng, Chengueng; Vykhodtseva, Natalia; Golby, Alexandra J; Reardon, David A

A dose finding clinical trial of cabozantinib (XL184) administered in combination with abiraterone acetate in metastatic castration-resistant prostate cancer

卡博替尼(XL184)联合醋酸阿比特龙治疗转移性去势抵抗性前列腺癌的剂量探索性临床试验

Choudhury, Atish D; Gray, Kathryn P; Supko, Jeffrey G; Harshman, Lauren C; Taplin, Mary-Ellen; Pace, Amanda F; Farina, Matthew; Zukotynski, Katherine A; Bernard, Brandon; Kantoff, Philip W; Pomerantz, Mark; Sweeney, Christopher

Feasibility, phase I, and phase II studies of tandutinib, an oral platelet-derived growth factor receptor-β tyrosine kinase inhibitor, in patients with recurrent glioblastoma.

坦度替尼(一种口服血小板衍生生长因子受体β酪氨酸激酶抑制剂)在复发性胶质母细胞瘤患者中的可行性、I期和II期研究

Batchelor Tracy T, Gerstner Elizabeth R, Ye Xiaobu, Desideri Serena, Duda Daniel G, Peereboom David, Lesser Glenn J, Chowdhary Sajeel, Wen Patrick Y, Grossman Stuart, Supko Jeffrey G