日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations

利用计算方法设计具有更高开发性的治疗性抗体:高效遍历结合物分布图和挽救逃逸突变

Frédéric A Dreyer ,Constantin Schneider ,Aleksandr Kovaltsuk ,Daniel Cutting ,Matthew J Byrne ,Daniel A Nissley ,Henry Kenlay ,Claire Marks ,David Errington ,Richard J Gildea ,David Damerell ,Pedro Tizei ,Wilawan Bunjobpol ,John F Darby ,Ieva Drulyte ,Daniel L Hurdiss ,Sachin Surade ,Newton Wahome ,Douglas E V Pires ,Charlotte M Deane

Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies

针对T细胞恶性肿瘤中TRBC1和TRBC2的结构导向免疫疗法工程

Mathieu Ferrari # ,Matteo Righi # ,Vania Baldan ,Patrycja Wawrzyniecka ,Anna Bulek ,Alexander Kinna ,Biao Ma ,Reyisa Bughda ,Zulaikha Akbar ,Saket Srivastava ,Isaac Gannon ,Mathew Robson ,James Sillibourne ,Ram Jha ,Mohamed El-Kholy ,Oliver Muhammad Amin ,Evangelia Kokalaki ,Mohammed Amin Banani ,Rehan Hussain ,William Day ,Wen Chean Lim ,Priyanka Ghongane ,Jade R Hopkins ,Dennis Jungherz ,Marco Herling ,Martin Welin ,Sachin Surade ,Michael Dyson ,John McCafferty ,Derek Logan ,Shaun Cordoba ,Simon Thomas ,Andrew Sewell ,Paul Maciocia ,Shimobi Onuoha ,Martin Pule

Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

超越亲和力:从哺乳动物展示文库中筛选具有最佳生物物理特性和降低免疫原性的抗体变体

Michael R Dyson ,Edward Masters ,Deividas Pazeraitis ,Rajika L Perera ,Johanna L Syrjanen ,Sachin Surade ,Nels Thorsteinson ,Kothai Parthiban ,Philip C Jones ,Maheen Sattar ,Gordana Wozniak-Knopp ,Florian Rueker ,Rachael Leah ,John McCafferty

A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing

利用基因编辑创建的大型哺乳动物展示文库全面搜索功能序列空间

Kothai Parthiban, Rajika L Perera, Maheen Sattar, Yanchao Huang, Sophie Mayle, Edward Masters, Daniel Griffiths, Sachin Surade, Rachael Leah, Michael R Dyson, John McCafferty

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays

片段大小的EthR抑制剂在全细胞结核分枝杆菌试验中表现出异常强的乙硫异烟胺增效作用

Nikiforov, Petar O; Blaszczyk, Michal; Surade, Sachin; Boshoff, Helena I; Sajid, Andaleeb; Delorme, Vincent; Deboosere, Nathalie; Brodin, Priscille; Baulard, Alain R; Barry, Clifton E 3rd; Blundell, Tom L; Abell, Chris

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

基于片段的结核分枝杆菌 CYP121 抑制剂开发方法

Madeline E Kavanagh, Anthony G Coyne, Kirsty J McLean, Guy G James, Colin W Levy, Leonardo B Marino, Luiz Pedro S de Carvalho, Daniel S H Chan, Sean A Hudson, Sachin Surade, David Leys, Andrew W Munro, Chris Abell

Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121

克服片段合并的局限性:拯救靶向结核分枝杆菌CYP121的受损合并片段系列

Hudson, Sean A; Surade, Sachin; Coyne, Anthony G; McLean, Kirsty J; Leys, David; Munro, Andrew W; Abell, Chris