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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

新形态 IDH 突变产生的 2-羟基戊二酸可抑制同源重组并诱导 PARP 抑制剂敏感性

Parker L Sulkowski, Christopher D Corso, Nathaniel D Robinson, Susan E Scanlon, Karin R Purshouse, Hanwen Bai, Yanfeng Liu, Ranjini K Sundaram, Denise C Hegan, Nathan R Fons, Gregory A Breuer, Yuanbin Song, Ketu Mishra-Gorur, Henk M De Feyter, Robin A de Graaf, Yulia V Surovtseva, Maureen Kachman, S

信号转导

发表日期：2017

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Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy

miniPEG-γ 修饰的 PNA 抑制 MicroRNA-210 的抗肿瘤活性，用于癌症治疗

期刊:Molecular Therapy-Nucleic Acids

影响因子:6.5

doi:10.1016/j.omtn.2017.09.001

Anisha Gupta, Elias Quijano, Yanfeng Liu, Raman Bahal, Susan E Scanlon, Eric Song, Wei-Che Hsieh, Demetrios E Braddock, Danith H Ly, W Mark Saltzman, Peter M Glazer

肿瘤

发表日期：2017

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Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells

镍诱导致瘤性和非致瘤性肺细胞中 DNA 修复途径的转录下调

期刊:Carcinogenesis

影响因子:3.3

doi:10.1093/carcin/bgx038

Susan E Scanlon, Christine D Scanlon, Denise C Hegan, Parker L Sulkowski, Peter M Glazer

Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma

抑制同源性依赖的 DNA 双链断裂修复可诱导 VHL 缺陷型人肾细胞癌对 PARP 抑制剂产生敏感性

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.23470

Susan E Scanlon, Denise C Hegan, Parker L Sulkowski, Peter M Glazer

Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins

缺氧应激促进范可尼贫血蛋白的急性激活和慢性下调

期刊:Molecular Cancer Research

影响因子:4.1

doi:10.1158/1541-7786.MCR-13-0628

Susan E Scanlon, Peter M Glazer

PTEN Regulates Nonhomologous End Joining By Epigenetic Induction of NHEJ1/XLF

PTEN 通过表观遗传诱导 NHEJ1/XLF 来调节非同源末端连接

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

新形态 IDH 突变产生的 2-羟基戊二酸可抑制同源重组并诱导 PARP 抑制剂敏感性

Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy

miniPEG-γ 修饰的 PNA 抑制 MicroRNA-210 的抗肿瘤活性，用于癌症治疗

Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells

镍诱导致瘤性和非致瘤性肺细胞中 DNA 修复途径的转录下调

Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma

抑制同源性依赖的 DNA 双链断裂修复可诱导 VHL 缺陷型人肾细胞癌对 PARP 抑制剂产生敏感性

Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins

缺氧应激促进范可尼贫血蛋白的急性激活和慢性下调