日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

快速诱导多能干细胞包涵体病模型揭示了α-突触核蛋白包涵体的形成、后果和分子亚型

Isabel Lam ,Alain Ndayisaba ,Amanda J Lewis ,YuHong Fu ,Giselle T Sagredo ,Anastasia Kuzkina ,Ludovica Zaccagnini ,Meral Celikag ,Jackson Sandoe ,Ricardo L Sanz ,Aazam Vahdatshoar ,Timothy D Martin ,Nader Morshed ,Toru Ichihashi ,Arati Tripathi ,Nagendran Ramalingam ,Charlotte Oettgen-Suazo ,Theresa Bartels ,Manel Boussouf ,Max Schäbinger ,Erinc Hallacli ,Xin Jiang ,Amrita Verma ,Challana Tea ,Zichen Wang ,Hiroyuki Hakozaki ,Xiao Yu ,Kelly Hyles ,Chansaem Park ,Xinyuan Wang ,Thorold W Theunissen ,Haoyi Wang ,Rudolf Jaenisch ,Susan Lindquist ,Beth Stevens ,Nadia Stefanova ,Gregor Wenning ,Wilma D J van de Berg ,Kelvin C Luk ,Rosario Sanchez-Pernaute ,Juan Carlos Gómez-Esteban ,Daniel Felsky ,Yasujiro Kiyota ,Nidhi Sahni ,S Stephen Yi ,Chee Yeun Chung ,Henning Stahlberg ,Isidro Ferrer ,Johannes Schöneberg ,Stephen J Elledge ,Ulf Dettmer ,Glenda M Halliday ,Tim Bartels ,Vikram Khurana

Telehealth in antenatal care: recent insights and advances

远程医疗在产前护理中的应用:最新见解和进展

Atkinson, Jessica; Hastie, Roxanne; Walker, Susan; Lindquist, Anthea; Tong, Stephen

The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

帕金森病蛋白α-突触核蛋白是加工体和mRNA稳定性的调节因子。

Erinc Hallacli ,Can Kayatekin ,Sumaiya Nazeen ,Xiou H Wang ,Zoe Sheinkopf ,Shubhangi Sathyakumar ,Souvarish Sarkar ,Xin Jiang ,Xianjun Dong ,Roberto Di Maio ,Wen Wang ,Matthew T Keeney ,Daniel Felsky ,Jackson Sandoe ,Aazam Vahdatshoar ,Namrata D Udeshi ,D R Mani ,Steven A Carr ,Susan Lindquist ,Philip L De Jager ,David P Bartel ,Chad L Myers ,J Timothy Greenamyre ,Mel B Feany ,Shamil R Sunyaev ,Chee Yeun Chung ,Vikram Khurana

HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state

HSF2 与 HSF1 协同驱动恶性状态所必需的转录程序

Roger S Smith, Seesha R Takagishi, David R Amici, Kyle Metz, Sitaram Gayatri, Milad J Alasady, Yaqi Wu, Sonia Brockway, Stephanie L Taiberg, Natalia Khalatyan, Mikko Taipale, Sandro Santagata, Luke Whitesell, Susan Lindquist, Jeffrey N Savas, Marc L Mendillo

Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML

抑制翻译起始因子 eIF4a 可使热休克因子 1 (HSF1) 失活并在 AML 中发挥抗白血病活性

Yuki Nishida, Ran Zhao, Lauren E Heese, Hiroki Akiyama, Shreya Patel, Alex M Jaeger, Rodrigo O Jacamo, Kensuke Kojima, Man Chun John Ma, Vivian R Ruvolo, Dhruv Chachad, William Devine, Susan Lindquist, R Eric Davis, John A Porco Jr, Luke Whitesell, Michael Andreeff, Jo Ishizawa

PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4

PICALM 挽救了阿尔茨海默病风险因子 APOE4 引起的内吞缺陷

Priyanka Narayan, Grzegorz Sienski, Julia M Bonner, Yuan-Ta Lin, Jinsoo Seo, Valeriya Baru, Aftabul Haque, Blerta Milo, Leyla A Akay, Agnese Graziosi, Yelena Freyzon, Dirk Landgraf, William R Hesse, Julie Valastyan, M Inmaculada Barrasa, Li-Huei Tsai, Susan Lindquist

Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition

瞬时 Hsp90 抑制可持续激活 mRNA 翻译

Peter Tsvetkov, Timothy J Eisen, Sven U Heinrich, Zarina Brune, Erinc Hallacli, Greg A Newby, Can Kayatekin, David Pincus, Susan Lindquist

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

致病真菌中 Hsp90 物种选择性靶向的结构基础

Luke Whitesell, Nicole Robbins, David S Huang, Catherine A McLellan, Tanvi Shekhar-Guturja, Emmanuelle V LeBlanc, Catherine S Nation, Raymond Hui, Ashley Hutchinson, Cathy Collins, Sharanya Chatterjee, Richard Trilles, Jinglin L Xie, Damian J Krysan, Susan Lindquist, John A Porco Jr, Utpal Tatu, Lau

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

脂质组学分析α-突触核蛋白神经毒性,发现硬脂酰辅酶A去饱和酶是帕金森病治疗的靶点

Saranna Fanning ,Aftabul Haque ,Thibaut Imberdis ,Valeriya Baru ,M Inmaculada Barrasa ,Silke Nuber ,Daniel Termine ,Nagendran Ramalingam ,Gary P H Ho ,Tallie Noble ,Jackson Sandoe ,Yali Lou ,Dirk Landgraf ,Yelena Freyzon ,Gregory Newby ,Frank Soldner ,Elizabeth Terry-Kantor ,Tae-Eun Kim ,Harald F Hofbauer ,Michel Becuwe ,Rudolf Jaenisch ,David Pincus ,Clary B Clish ,Tobias C Walther ,Robert V Farese Jr ,Supriya Srinivasan ,Michael A Welte ,Sepp D Kohlwein ,Ulf Dettmer ,Susan Lindquist ,Dennis Selkoe

Mitochondrial metabolism promotes adaptation to proteotoxic stress

线粒体代谢促进对蛋白质毒性应激的适应

Peter Tsvetkov, Alexandre Detappe, Kai Cai, Heather R Keys, Zarina Brune, Weiwen Ying, Prathapan Thiru, Mairead Reidy, Guillaume Kugener, Jordan Rossen, Mustafa Kocak, Nora Kory, Aviad Tsherniak, Sandro Santagata, Luke Whitesell, Irene M Ghobrial, John L Markley, Susan Lindquist, Todd R Golub