日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of diverse and functional antibodies from large human repertoire antibody libraries

从大型人类抗体库中发现多样化和功能性的抗体

Lauren J Schwimmer, Betty Huang, Hoa Giang, Robyn L Cotter, David S Chemla-Vogel, Francis V Dy, Eric M Tam, Fangjiu Zhang, Pamela Toy, David J Bohmann, Susan R Watson, John W Beaber, Nithin Reddy, Hua-Feng Kuan, Daniel H Bedinger, Isaac J Rondon

Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment

锌指蛋白 Zfp335 是幼稚 T 细胞区室形成所必需的

Brenda Y Han, Shuang Wu, Chuan-Sheng Foo, Robert M Horton, Craig N Jenne, Susan R Watson, Belinda Whittle, Chris C Goodnow, Jason G Cyster

Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia

人类变构单克隆抗体抑制胰岛素受体功能:治疗高胰岛素血症性低血糖症的潜在新方法

John A Corbin, Vinay Bhaskar, Ira D Goldfine, Hassan Issafras, Daniel H Bedinger, Angela Lau, Kristen Michelson, Lisa M Gross, Betty A Maddux, Hua F Kuan, Catarina Tran, Llewelyn Lao, Masahisa Handa, Susan R Watson, Ajay J Narasimha, Shirley Zhu, Raphael Levy, Lynn Webster, Sujeewa D Wijesuriya, Nai

Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity

通过增加胰岛素受体结合亲和力的变构单克隆抗体改善体内和体外的葡萄糖代谢

John A Corbin, Vinay Bhaskar, Ira D Goldfine, Daniel H Bedinger, Angela Lau, Kristen Michelson, Lisa M Gross, Betty A Maddux, Hua F Kuan, Catarina Tran, Llewelyn Lao, Masahisa Handa, Susan R Watson, Ajay J Narasimha, Shirley Zhu, Raphael Levy, Lynn Webster, Sujeewa D Wijesuriya, Naichi Liu, Xiaorong

A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control

一种完全人源化变构单克隆抗体,可激活胰岛素受体并改善血糖控制

Vinay Bhaskar, Ira D Goldfine, Daniel H Bedinger, Angela Lau, Hua F Kuan, Lisa M Gross, Masahisa Handa, Betty A Maddux, Susan R Watson, Shirley Zhu, Ajay J Narasimha, Raphael Levy, Lynn Webster, Sujeewa D Wijesuriya, Naichi Liu, Xiaorong Wu, David Chemla-Vogel, Catarina Tran, Steve R Lee, Steve Wong

The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency

肌动蛋白调节剂冠蛋白 1A 在胸腺出口缺陷的小鼠品系和患有严重联合免疫缺陷的患者中发生突变

Lawrence R Shiow, David W Roadcap, Kenneth Paris, Susan R Watson, Irina L Grigorova, Tonya Lebet, Jinping An, Ying Xu, Craig N Jenne, Niko Föger, Ricardo U Sorensen, Christopher C Goodnow, James E Bear, Jennifer M Puck, Jason G Cyster